| Literature DB >> 16518402 |
Adam S Adler1, Meihong Lin, Hugo Horlings, Dimitry S A Nuyten, Marc J van de Vijver, Howard Y Chang.
Abstract
Gene expression signatures encompassing dozens to hundreds of genes have been associated with many important parameters of cancer, but mechanisms of their control are largely unknown. Here we present a method based on genetic linkage that can prospectively identify functional regulators driving large-scale transcriptional signatures in cancer. Using this method we show that the wound response signature, a poor-prognosis expression pattern of 512 genes in breast cancer, is induced by coordinate amplifications of MYC and CSN5 (also known as JAB1 or COPS5). This information enabled experimental recapitulation, functional assessment and mechanistic elucidation of the wound signature in breast epithelial cells.Entities:
Mesh：
Year: 2006 PMID： 16518402 PMCID： PMC1435790 DOI： 10.1038/ng1752
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330