Literature DB >> 16518128

Effects of methylphenidate on cognitive function and gait in patients with Parkinson's disease: a pilot study.

Eitan Auriel1, Jeffrey M Hausdorff, Talia Herman, Ely S Simon, Nir Giladi.   

Abstract

Twenty-one patients with Parkinson's disease were studied before and 2 h after the administration of a single dose of 20 mg of methylphenidate. In response to methylphenidate, attention significantly improved, whereas memory and visual-spatial performance were unchanged. Gait speed, stride time variability, and Timed Up and Go times (demonstrated measures of fall risk) significantly improved. These findings suggest a new potential pharmacologic means of enhancing mobility and decreasing fall risk in Parkinson's disease.

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Year:  2006        PMID： 16518128     DOI： 10.1097/00002826-200601000-00005

Source DB:  PubMed          Journal:  Clin Neuropharmacol        ISSN： 0362-5664            Impact factor:   1.592


  41 in total

1.  Gait asymmetry in patients with Parkinson's disease and elderly fallers: when does the bilateral coordination of gait require attention?

Authors:  Galit Yogev; Meir Plotnik; Chava Peretz; Nir Giladi; Jeffrey M Hausdorff
Journal:  Exp Brain Res       Date:  2007-03       Impact factor: 1.972

2.  Gait and mental function: the interplay between walking, behavior and cognition.

Authors:  N Giladi
Journal:  J Neural Transm (Vienna)       Date:  2007       Impact factor: 3.575

Review 3.  Gait dynamics, fractals and falls: finding meaning in the stride-to-stride fluctuations of human walking.

Authors:  Jeffrey M Hausdorff
Journal:  Hum Mov Sci       Date:  2007-07-05       Impact factor: 2.161

Review 4.  Gait dynamics in Parkinson's disease: common and distinct behavior among stride length, gait variability, and fractal-like scaling.

Authors:  Jeffrey M Hausdorff
Journal:  Chaos       Date:  2009-06       Impact factor: 3.642

Review 5.  Monoamine reuptake inhibitors in Parkinson's disease.

Authors:  Philippe Huot; Susan H Fox; Jonathan M Brotchie
Journal:  Parkinsons Dis       Date:  2015-02-25

Review 6.  Treatment of cognitive, psychiatric, and affective disorders associated with Parkinson's disease.

Authors:  Barbara Connolly; Susan H Fox
Journal:  Neurotherapeutics       Date:  2014-01       Impact factor: 7.620

7.  Methylphenidate-induced alterations in synaptic vesicle trafficking and activity.

Authors:  Trent J Volz; Sarah J Farnsworth; Glen R Hanson; Annette E Fleckenstein
Journal:  Ann N Y Acad Sci       Date:  2008-10       Impact factor: 5.691

Review 8.  Novel therapeutic strategies in Parkinson's disease.

Authors:  Peter Klivenyi; Laszlo Vecsei
Journal:  Eur J Clin Pharmacol       Date:  2009-10-16       Impact factor: 2.953

9.  Identifying axial and cognitive correlates in patients with Parkinson's disease motor subtype using the instrumented Timed Up and Go.

Authors:  Talia Herman; Aner Weiss; Marina Brozgol; Nir Giladi; Jeffrey M Hausdorff
Journal:  Exp Brain Res       Date:  2013-11-30       Impact factor: 1.972

Review 10.  Postural instability in patients with Parkinson's disease. Epidemiology, pathophysiology and management.

Authors:  Samuel D Kim; Natalie E Allen; Colleen G Canning; Victor S C Fung
Journal:  CNS Drugs       Date:  2013-02       Impact factor: 5.749
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