| Literature DB >> 16518074 |
Tsuyoshi Nishihashi1, Cristina C Trandafir, Aimin Wang, Xu Ji, Yoshiharu Shimizu, Kazuyoshi Kurahashi.
Abstract
Vasospasm after subarachnoid hemorrhage (SAH) is a serious complication and we have been investigating the relationship between vasoconstrictors and vasospasm after SAH. The present study was designed to investigate the vasocontractile responses to reactive oxygen species in isolated rat basilar arteries from the control and experimental SAH rats. Contractile responses to hydroxyl radicals in basilar arteries from SAH rats were 3-6-fold higher than those in control rats. The present results clearly indicate that hypersensitivity to hydroxyl radicals may contribute to the vasospasm after SAH.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16518074 DOI： 10.1254/jphs.sc0050160
Source DB: PubMed Journal: J Pharmacol Sci ISSN： 1347-8613 Impact factor: 3.337