| Literature DB >> 16517200 |
Teruyuki Hayakawa1, Atsushi Matsuzawa, Takuya Noguchi, Kohsuke Takeda, Hidenori Ichijo.
Abstract
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate immunity, and the evolutionary perspectives.Entities:
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Year: 2006 PMID: 16517200 DOI: 10.1016/j.micinf.2005.12.001
Source DB: PubMed Journal: Microbes Infect ISSN: 1286-4579 Impact factor: 2.700