| Literature DB >> 16517065 |
Janaina Fernandes1, Ricardo Weinlich, Rachel Oliveira Castilho, Gustavo Pessini Amarante-Mendes, Cerli Rocha Gattass.
Abstract
Multidrug resistance (MDR) is multifactorial and may be mediated by overexpression of anti-apoptotic proteins. This paper investigated whether pomolic acid (PA) was able to overcome resistance mediated by overexpression of Bcl-2 or BcL-xL. The results obtained showed that overexpression of these proteins partially inhibited the PA-induced apoptosis, loss of mitochondrial membrane potential and caspase -3 and -9 activation observed in HL-60/neo. Since Bcl-2 transfected cell lines were shown to be quite resistant to a series of chemotherapeutic agents, the data presented call attention to the possible clinical significance of PA as an anti-MDR drug.Entities:
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Year: 2006 PMID： 16517065 DOI： 10.1016/j.canlet.2006.01.009
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679