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Literature DB >> 16515473

Rho-kinase as a drug target for the treatment of airway hyperrespon-siveness in asthma.

Reinoud Gosens¹, Dedmer Schaafsma, S Adriaan Nelemans, Andrew J Halayko.

Abstract

In asthma, inflammatory and structural cells contribute to increased bronchoconstriction acutely and more chronically to airway remodelling. Current asthma therapy doesn't inhibit these features satisfactorily. This review discusses Rho-kinase as a potential drug target, since increasing evidence suggests a central role for this pathway in acute and chronic airway hyperresponsiveness.

Entities: Disease

Mesh：

Substances：
rhoA GTP-Binding Protein

Year: 2006 PMID： 16515473 DOI： 10.2174/138955706776073402

Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862

Keyword Cloud
Cited

18 in total

Review 1. Motility, survival, and proliferation.

Authors: William T Gerthoffer; Dedmer Schaafsma; Pawan Sharma; Saeid Ghavami; Andrew J Halayko
Journal: Compr Physiol Date: 2012-01 Impact factor: 9.090

2. Short-term roxithromycin treatment attenuates airway inflammation via MAPK/NF-κB activation in a mouse model of allergic asthma.

Authors: Xinxin Ci; Xiao Chu; Xue Xu; Hongyu Li; Xuming Deng
Journal: Inflamm Res Date: 2012-04-06 Impact factor: 4.575

3. Insulin induces airway smooth muscle contraction.

Authors: D Schaafsma; R Gosens; J M Ris; J Zaagsma; H Meurs; S A Nelemans
Journal: Br J Pharmacol Date: 2006-12-11 Impact factor: 8.739

4. The proximal STAT6 and NF-kappaB sites are responsible for IL-13- and TNF-alpha-induced RhoA transcriptions in human bronchial smooth muscle cells.

Authors: Kumiko Goto; Yoshihiko Chiba; Kimihiko Matsusue; Yoshiyuki Hattori; Yoshie Maitani; Hiroyasu Sakai; Shioko Kimura; Miwa Misawa
Journal: Pharmacol Res Date: 2009-12-17 Impact factor: 7.658

5. Brain-derived neurotrophic factor in TNF-alpha modulation of Ca2+ in human airway smooth muscle.

Authors: Y S Prakash; Michael A Thompson; Christina M Pabelick
Journal: Am J Respir Cell Mol Biol Date: 2009-02-12 Impact factor: 6.914

Review 6. Potential adverse effects of bronchodilators in the treatment of airways obstruction in older people: recommendations for prescribing.

Authors: Preeti Gupta; M Sinead O'Mahony
Journal: Drugs Aging Date: 2008 Impact factor: 3.923

Rho-kinase as a drug target for the treatment of airway hyperrespon-siveness in asthma.

Review 1. Motility, survival, and proliferation.

2. Short-term roxithromycin treatment attenuates airway inflammation via MAPK/NF-κB activation in a mouse model of allergic asthma.

3. Insulin induces airway smooth muscle contraction.

4. The proximal STAT6 and NF-kappaB sites are responsible for IL-13- and TNF-alpha-induced RhoA transcriptions in human bronchial smooth muscle cells.

5. Brain-derived neurotrophic factor in TNF-alpha modulation of Ca2+ in human airway smooth muscle.

Review 6. Potential adverse effects of bronchodilators in the treatment of airways obstruction in older people: recommendations for prescribing.

7. Arhgef1 is required by T cells for the development of airway hyperreactivity and inflammation.

Review 8. Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones.

Review 9. Emerging targets for novel therapy of asthma.

10. alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression.