Literature DB >> 16515472

Effects of the natural isoflavonoid genistein on growth, signaling pathways and gene expression of matrix macromolecules by breast cancer cells.

O Ch Kousidou1, G N Tzanakakis, N K Karamanos.   

Abstract

Genistein is a well known protein tyrosine kinase inhibitor. It is structurally similar to 17beta-estradiol and exerts antiestrogenic effects. It also affects the signal transduction components Akt, FAK, ErbB-2 and Bcl-2. Key enzymes implicated in cancer invasion are also affected by genistein. A critical evaluation of the effects of genistein on breast cancer growth, signaling and gene expression is presented in this review.

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Year:  2006        PMID： 16515472     DOI： 10.2174/138955706776073420

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  14 in total

1.  Neuroprotective effects of genistein in VSC4.1 motoneurons exposed to activated microglial cytokines.

Authors:  Misty L McDowell; Arabinda Das; Joshua A Smith; Abhay K Varma; Swapan K Ray; Naren L Banik
Journal:  Neurochem Int       Date:  2011-06-06       Impact factor: 3.921

Review 2.  Endocrine disruption via estrogen receptors that participate in nongenomic signaling pathways.

Authors:  Cheryl S Watson; Yow-Jiun Jeng; Jutatip Guptarak
Journal:  J Steroid Biochem Mol Biol       Date:  2011-02-12       Impact factor: 4.292

3.  Sex hormone modulation of both induction and inhibition of CYP1A by genistein in HepG2/C3A cells.

Authors:  Yitong Liu; Michael F Santillo; Thomas J Flynn; Martine S Ferguson
Journal:  In Vitro Cell Dev Biol Anim       Date:  2014-12-06       Impact factor: 2.416

4.  Isoflavonoids - an overview of their biological activities and potential health benefits.

Authors:  Eva Miadoková
Journal:  Interdiscip Toxicol       Date:  2009-12-28

5.  Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing.

Authors:  Remo Gräub; Hope Lancero; Anissa Pedersen; Meihua Chu; Krishnan Padmanabhan; Xiao-Qin Xu; Paul Spitz; Robert Chalkley; Alma L Burlingame; David Stokoe; Harold S Bernstein
Journal:  Cell Cycle       Date:  2008-06-25       Impact factor: 4.534

6.  Genistein induction of human sulfotransferases in HepG2 and Caco-2 cells.

Authors:  Yue Chen; Chaoqun Huang; Tianyan Zhou; Guangping Chen
Journal:  Basic Clin Pharmacol Toxicol       Date:  2008-12       Impact factor: 4.080

7.  Heavy water labeling method for measuring the effect of genistein on mammary gland carcinogenesis.

Authors:  Hyeon-A Kim; Kyu-Shik Jeong; Dae-Hun Park; Jeong-Ae Lee; Won-Il Jeong; Yoo Kyeong Kim
Journal:  Mol Cell Biochem       Date:  2007-02-21       Impact factor: 3.842

8.  Individual and combined soy isoflavones exert differential effects on metastatic cancer progression.

Authors:  Michelle M Martínez-Montemayor; Elisa Otero-Franqui; Joel Martinez; Alina De La Mota-Peynado; Luis A Cubano; Suranganie Dharmawardhane
Journal:  Clin Exp Metastasis       Date:  2010-06-02       Impact factor: 5.150

9.  Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells.

Authors:  Yue Chen; Shunfen Zhang; Tianyan Zhou; Chaoqun Huang; Alicia McLaughlin; Guangping Chen
Journal:  Toxicol Appl Pharmacol       Date:  2013-01-23       Impact factor: 4.219

Review 10.  Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.

Authors:  Axel H Schönthal
Journal:  Scientifica (Cairo)       Date:  2012-12-23
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