| Literature DB >> 16515041 |
V L Andronova, A A Pchelintseva, A V Ustinov, A L Petrunina, V A Korshun, M V Skorobogatyĭ, G A Galegov.
Abstract
A series of new 5-alkynyl-2'-deoxyuridines have been synthesized and their antiherpetic activity was tested in the cultured Vero cells on a model of herpes simplex virus type 1, including its acyclovir-resistant strains. Some test compounds were found to have a significant specific antiherpetic activity. Nucleoside XIV showed the greatest activity. Compounds IV and X also has displayed a significant activity against the herpes simplex virus type 1 strain that is highly resistant to acyclovir. Examining the combined action of substance II with acyclovir and ganciclovir has revealed a synergetic effect.Entities:
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Year: 2006 PMID： 16515041
Source DB: PubMed Journal: Vopr Virusol ISSN： 0507-4088