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Literature DB >> 16514440

Glycoconjugates of gadolinium complexes for MRI applications.

David A Fulton¹, Elisa M Elemento, Silvio Aime, Linda Chaabane, Mauro Botta, David Parker.

Abstract

Examples of C-4 symmetric, medium MW conjugates incorporating 12 glucose or galactose groups linked via four dendritic wedges to a central Gd complex have been characterised; their enhanced relaxivity is interpreted in terms of effective motional coupling and large contributions from second sphere water molecules.

Entities: Chemical Gene

Mesh：

Substances：
Gadolinium
Glucose

Year: 2006 PMID： 16514440 DOI： 10.1039/b517997a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

Keyword Cloud
Cited

12 in total

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4. Enhanced MRI relaxivity of Gd(3+) -based contrast agents geometrically confined within porous nanoconstructs.

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5. The interaction of La(3+) complexes of DOTA/DTPA glycoconjugates with the RCA(120) lectin: a saturation transfer difference NMR spectroscopic study.

Authors: João M C Teixeira; David M Dias; F Javier Cañada; José A Martins; João P André; Jesús Jiménez-Barbero; Carlos F G C Geraldes
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6. Influence of molecular parameters and increasing magnetic field strength on relaxivity of gadolinium- and manganese-based T1 contrast agents.

Authors: Peter Caravan; Christian T Farrar; Luca Frullano; Ritika Uppal
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Glycoconjugates of gadolinium complexes for MRI applications.

1. Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease.

Review 2. Macromolecules, dendrimers, and nanomaterials in magnetic resonance imaging: the interplay between size, function, and pharmacokinetics.

3. Protein MRI contrast agent with unprecedented metal selectivity and sensitivity for liver cancer imaging.

4. Enhanced MRI relaxivity of Gd(3+) -based contrast agents geometrically confined within porous nanoconstructs.

5. The interaction of La(3+) complexes of DOTA/DTPA glycoconjugates with the RCA(120) lectin: a saturation transfer difference NMR spectroscopic study.

6. Influence of molecular parameters and increasing magnetic field strength on relaxivity of gadolinium- and manganese-based T1 contrast agents.

Review 7. Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

8. Gd(DOTAla): a single amino acid Gd-complex as a modular tool for high relaxivity MR contrast agent development.

9. Macromolecular Imaging Agents Containing Lanthanides: Can Conceptual Promise Lead to Clinical Potential?

10. GRPR-targeted Protein Contrast Agents for Molecular Imaging of Receptor Expression in Cancers by MRI.