| Literature DB >> 1651383 |
S Pappata1, P Cornu, Y Samson, C Prenant, J Benavides, B Scatton, C Crouzel, J J Hauw, A Syrota.
Abstract
The utility of the peripheral type benzodiazepine site ligand 11C-PK 11195, for imaging human glioma in conjunction with Positron Emission Tomography, relies on a high specific binding of the tracer to tumoral peripheral type benzodiazepines sites. In a patient with glioblastoma, we found that 11C-PK 11195 binding was two-fold higher in the tumor than in normal gray matter and that 30% of tumoral binding could be displaced by a large excess of unlabeled drug. These findings suggest that tumoral retention of the ligand is due, in part, to specific binding.Entities:
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Year: 1991 PMID： 1651383
Source DB: PubMed Journal: J Nucl Med ISSN： 0161-5505 Impact factor: 10.057