BACKGROUND: Recently published evidence has identified thinner central corneal thickness (CCT) as a strong predictive factor for the conversion from ocular hypertension (OHT) to primary open-angle glaucoma (POAG). The association between CCT and development of normal-tension glaucoma (NTG), however, is less clear. Accordingly, we designed this cross-sectional study to further explore the relationship between CCT and NTG. PATIENTS AND METHODS: All patients with a clinical diagnosis of NTG and NTG suspect (NTGS) who were seen from September 2002 through May 2003 at the Albuquerque VA Medical Center eye clinic were identified retrospectively. After eligible subjects were categorized into no, mild, moderate, and advanced visual field loss groups, analysis of variance (ANOVA) and regression analyses were used to determine group differences for several IOP variables, several systemic variables, and CCT. Additional analyses were completed after eligible subjects were recategorized into thin, intermediate, and thick CCT groups. RESULTS: Eighty-four eyes in 84 NTGS subjects and 56 eyes in 56 NTG subjects were studied. Mean CCT was significantly thicker in the no field loss group (NTGS) when compared with all 3 groups with glaucomatous visual field loss (NTG). In multivariate regression analysis, the association between CCT and the presence of NTG-related visual field loss was robust and independent. Conversely, no relationship was found between CCT and severity of NTG-related visual field loss. CONCLUSIONS: In eyes characterized by statistically normal intraocular pressure (IOP) measurements as measured by Goldmann applanation tonometry, we found a significant relationship between CCT and the presence, but not severity, of glaucomatous visual field loss. A prospective study is required to further explore and confirm these relationships.
BACKGROUND: Recently published evidence has identified thinner central corneal thickness (CCT) as a strong predictive factor for the conversion from ocular hypertension (OHT) to primary open-angle glaucoma (POAG). The association between CCT and development of normal-tension glaucoma (NTG), however, is less clear. Accordingly, we designed this cross-sectional study to further explore the relationship between CCT and NTG. PATIENTS AND METHODS: All patients with a clinical diagnosis of NTG and NTG suspect (NTGS) who were seen from September 2002 through May 2003 at the Albuquerque VA Medical Center eye clinic were identified retrospectively. After eligible subjects were categorized into no, mild, moderate, and advanced visual field loss groups, analysis of variance (ANOVA) and regression analyses were used to determine group differences for several IOP variables, several systemic variables, and CCT. Additional analyses were completed after eligible subjects were recategorized into thin, intermediate, and thick CCT groups. RESULTS: Eighty-four eyes in 84 NTGS subjects and 56 eyes in 56 NTG subjects were studied. Mean CCT was significantly thicker in the no field loss group (NTGS) when compared with all 3 groups with glaucomatous visual field loss (NTG). In multivariate regression analysis, the association between CCT and the presence of NTG-related visual field loss was robust and independent. Conversely, no relationship was found between CCT and severity of NTG-related visual field loss. CONCLUSIONS: In eyes characterized by statistically normal intraocular pressure (IOP) measurements as measured by Goldmann applanation tonometry, we found a significant relationship between CCT and the presence, but not severity, of glaucomatous visual field loss. A prospective study is required to further explore and confirm these relationships.
Authors: Megan Ulmer; Jun Li; Brian L Yaspan; Ayse Bilge Ozel; Julia E Richards; Sayoko E Moroi; Felicia Hawthorne; Donald L Budenz; David S Friedman; Douglas Gaasterland; Jonathan Haines; Jae H Kang; Richard Lee; Paul Lichter; Yutao Liu; Louis R Pasquale; Margaret Pericak-Vance; Anthony Realini; Joel S Schuman; Kuldev Singh; Douglas Vollrath; Robert Weinreb; Gadi Wollstein; Donald J Zack; Kang Zhang; Terri Young; R Rand Allingham; Janey L Wiggs; Allison Ashley-Koch; Michael A Hauser Journal: Invest Ophthalmol Vis Sci Date: 2012-07-03 Impact factor: 4.799