| Literature DB >> 16513349 |
Sung Jin Cho1, Jung Seop Roh, Won Suck Sun, Sung Han Kim, Ki Duk Park.
Abstract
A series of potent inhibitors of tyrosinase and their structure-activity relationships are described. N-Benzylbenzamide derivatives (1-21) with hydroxyl(s) were synthesized and tested for their tyrosinase inhibitory activity. With this series, compound 15 provided a potent tyrosinase inhibition: it effectively inhibited the oxidation of l-DOPA catalyzed by mushroom tyrosinase with an IC(50) of 2.2microM.Entities:
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Year: 2006 PMID： 16513349 DOI： 10.1016/j.bmcl.2006.02.018
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823