| Literature DB >> 16513345 |
Esther del Olmo1, Bianca Barboza, Maria Inés Ybarra, José Luis López-Pérez, Rosalía Carrón, Maria Angeles Sevilla, Cinthia Boselli, Arturo San Feliciano.
Abstract
Several series of dihydrostilbenamide, imidazo[2,1-a]isoindole, pyrimido[2,1-a]isoindole and phthalazinone derivatives were obtained and their vasorelaxant activity was measured on isolated rat aorta rings pre-contracted with phenylephrine (10(-5)M). Some phthalazinones attained, practically, the total relaxation of the organ at micromolar concentrations. For the most potent compound 9h (EC(50)=0.43microM) the affinities for alpha(1A), alpha(1B) and alpha(1D) adrenergic sub-receptors were determined.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16513345 DOI： 10.1016/j.bmcl.2006.02.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823