| Literature DB >> 16513343 |
Graham A Showell1, Matthew J Barnes, Jürgen O Daiss, John S Mills, John G Montana, Reinhold Tacke, Julie B H Warneck.
Abstract
Sila-substitution of drugs (the carbon/silicon switch) is a concept that is being successfully used for the development of new chemical entities. The (R)-sila-analogue of the antidepressant venlafaxine is devoid of the serotonin reuptake inhibition observed with the marketed drug, leading to a selective noradrenaline reuptake inhibitor displaying anti-emetic properties.Entities:
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Year: 2006 PMID： 16513343 DOI： 10.1016/j.bmcl.2005.12.062
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823