Literature DB >> 16513256

The role of tamoxifen in combination with cisplatin on oral squamous cell carcinoma cell lines.

Myung-Jin Kim1, Jong-Ho Lee, Young-Kyun Kim, Hoon Myoung, Pil-Young Yun.   

Abstract

The purpose of this study was to evaluate the effect of tamoxifen (TAM) when used in combination with cisplatin on oral squamous cell carcinoma (OSCC). For this, the relation between estrogen receptor (ER) expression level and the cytotoxic effect of TAM, the apoptotic effect and its molecular mechanisms of TAM were investigated using OSCC cell lines. Combination treatment demonstrated a superior cytotoxic and apoptotic effect on OSCC cell lines. Considerable amount of ER was detected in some OSCC cell lines, but there were no significant differences of cytotoxic effect of TAM. TAM inhibited PKC activity and up-regulated TGF-beta1 secretion.

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Year:  2006        PMID： 16513256     DOI： 10.1016/j.canlet.2006.01.017

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  8 in total

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Review 2.  Glycogen synthase kinase 3 beta: can it be a target for oral cancer.

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4.  Estrogen and Progesterone hormone receptor expression in oral cavity cancer.

Authors:  M Grimm; T Biegner; P Teriete; S Hoefert; M Krimmel; A Munz; S Reinert
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Review 5.  The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment.

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Review 6.  Insights Into the Role of Epigenetic Factors Determining the Estrogen Response in Estrogen-Positive Ovarian Cancer and Prospects of Combining Epi-Drugs With Endocrine Therapy.

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Journal:  Front Genet       Date:  2022-07-08       Impact factor: 4.772

7.  Relationship between Menopausal Hormone Therapy and Oral Cancer: A Cohort Study Based on the Health Insurance Database in South Korea.

Authors:  Jin-Sung Yuk; Bo Young Kim
Journal:  J Clin Med       Date:  2022-10-02       Impact factor: 4.964

8.  Microarray-assisted pathway analysis identifies MT1X & NFκB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma.

Authors:  Bo Peng; Yixue Gu; Yan Xiong; Guopei Zheng; Zhimin He
Journal:  PLoS One       Date:  2012-12-10       Impact factor: 3.240
  8 in total

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