Literature DB >> 16512662

Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS 1H NMR spectroscopy.

Tsz M Tsang1, Ben Woodman, Gerard A McLoughlin, Julian L Griffin, Sarah J Tabrizi, Gillian P Bates, Elaine Holmes.   

Abstract

The metabolic consequences of Huntington's disease in the R6/2 mouse model were investigated using NMR spectroscopy and pattern recognition to characterize selected brain regions, muscle, blood, and urine. Global increases in relative brain concentrations of osmolytes, creatine, glutamine, and lactate, and decreases in acetate and N-acetylaspartate were found together with striatal-specific lower concentrations of GABA and choline. Clear differentiation of R6/2 and wild-type mice was also obtained for urine and blood metabolite profiles that may have applicability for monitoring HD in human populations.

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Year:  2006        PMID： 16512662     DOI： 10.1021/pr050244o

Source DB:  PubMed          Journal:  J Proteome Res        ISSN： 1535-3893            Impact factor:   4.466


  30 in total

Review 1.  Acidosis, acid-sensing ion channels, and neuronal cell death.

Authors:  Yi-Zhi Wang; Tian-Le Xu
Journal:  Mol Neurobiol       Date:  2011-09-20       Impact factor: 5.590

2.  Cortical metabolites as biomarkers in the R6/2 model of Huntington's disease.

Authors:  Lori Zacharoff; Ivan Tkac; Qingfeng Song; Chuanning Tang; Patrick J Bolan; Silvia Mangia; Pierre-Gilles Henry; Tongbin Li; Janet M Dubinsky
Journal:  J Cereb Blood Flow Metab       Date:  2011-11-02       Impact factor: 6.200

Review 3.  The application of NMR-based metabonomics in neurological disorders.

Authors:  Elaine Holmes; Tsz M Tsang; Sarah J Tabrizi
Journal:  NeuroRx       Date:  2006-07

Review 4.  The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease.

Authors:  Ignacio Munoz-Sanjuan; Gillian P Bates
Journal:  J Clin Invest       Date:  2011-02-01       Impact factor: 14.808

Review 5.  Preclinical (1)H-MRS neurochemical profiling in neurological and psychiatric disorders.

Authors:  Moonnoh R Lee; Aleksandar Denic; David J Hinton; Prasanna K Mishra; Doo-Sup Choi; Istvan Pirko; Moses Rodriguez; Slobodan I Macura
Journal:  Bioanalysis       Date:  2012-07       Impact factor: 2.681

6.  Homeostatic adaptations in brain energy metabolism in mouse models of Huntington disease.

Authors:  Ivan Tkac; Pierre-Gilles Henry; Lori Zacharoff; Michael Wedel; Wuming Gong; Dinesh K Deelchand; Tongbin Li; Janet M Dubinsky
Journal:  J Cereb Blood Flow Metab       Date:  2012-07-18       Impact factor: 6.200

Review 7.  Novel Insights into Acid-Sensing Ion Channels: Implications for Degenerative Diseases.

Authors:  Ren-Peng Zhou; Xiao-Shan Wu; Zhi-Sen Wang; Ya-Ya Xie; Jin-Fang Ge; Fei-Hu Chen
Journal:  Aging Dis       Date:  2015-12-13       Impact factor: 6.745

8.  Metabonomic characterization of the 3-nitropropionic acid rat model of Huntington's disease.

Authors:  T M Tsang; J N Haselden; E Holmes
Journal:  Neurochem Res       Date:  2009-01-16       Impact factor: 3.996

9.  Probing the metabolic aberrations underlying mutant huntingtin toxicity in yeast and assessing their degree of preservation in humans and mice.

Authors:  P Matthew Joyner; Ronni M Matheke; Lindsey M Smith; Robert H Cichewicz
Journal:  J Proteome Res       Date:  2010-01       Impact factor: 4.466

10.  Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation.

Authors:  Ji-Kyung Choi; Ekkehard Küstermann; Alpaslan Dedeoglu; Bruce G Jenkins
Journal:  Eur J Neurosci       Date:  2009-11-20       Impact factor: 3.386
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