Literature DB >> 16511231

Crystallization and preliminary X-ray characterization of prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis.

Yoshitaka Nakajima1, Kiyoshi Ito, Yue Xu, Nozomi Yamada, Yuko Onohara, Takashi Ito, Tadashi Yoshimoto.   

Abstract

A recombinant form of prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis has been crystallized by the hanging-drop vapour-diffusion method using potassium sodium tartrate as a precipitating agent. The crystals belong to the hexagonal space group P6(3)22, with unit-cell parameters a = b = 149.4, c = 159.7 A. The crystals are most likely to contain one subunit of a dimer in the asymmetric unit, with a VM value of 3.14 A3 Da(-1). Diffraction data were collected to 2.1 A resolution using synchrotron radiation at the BL5 station of the Photon Factory.

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Year:  2005        PMID： 16511231      PMCID： PMC1978158          DOI： 10.1107/S1744309105035712

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


  13 in total

1.  Prolyl tripeptidyl peptidase from Porphyromonas gingivalis. A novel enzyme with possible pathological implications for the development of periodontitis.

Authors:  A Banbula; P Mak; M Bugno; J Silberring; A Dubin; D Nelson; J Travis; J Potempa
Journal:  J Biol Chem       Date:  1999-04-02       Impact factor: 5.157

2.  Matthews coefficient probabilities: Improved estimates for unit cell contents of proteins, DNA, and protein-nucleic acid complex crystals.

Authors:  Katherine A Kantardjieff; Bernhard Rupp
Journal:  Protein Sci       Date:  2003-09       Impact factor: 6.725

3.  The CCP4 suite: programs for protein crystallography.

Authors: 
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1994-09-01

4.  Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog.

Authors:  Hanne B Rasmussen; Sven Branner; Finn C Wiberg; Nicolai Wagtmann
Journal:  Nat Struct Biol       Date:  2003-01

5.  Processing of X-ray diffraction data collected in oscillation mode.

Authors:  Z Otwinowski; W Minor
Journal:  Methods Enzymol       Date:  1997       Impact factor: 1.600

6.  Detection of cathepsin B- and L-, elastase-, tryptase-, trypsin-, and dipeptidyl peptidase IV-like activities in crevicular fluid from gingivitis and periodontitis patients with peptidyl derivatives of 7-amino-4-trifluoromethyl coumarin.

Authors:  S W Cox; B M Eley
Journal:  J Periodontal Res       Date:  1989-11       Impact factor: 4.419

7.  The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold.

Authors:  Hajime Hiramatsu; Kiyoshi Kyono; Yutaka Higashiyama; Chiaki Fukushima; Hideaki Shima; Shigeru Sugiyama; Koji Inaka; Atsushi Yamamoto; Ryo Shimizu
Journal:  Biochem Biophys Res Commun       Date:  2003-03-21       Impact factor: 3.575

8.  Automated MAD and MIR structure solution.

Authors:  T C Terwilliger; J Berendzen
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1999-04

9.  The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism.

Authors:  Michael Engel; Torsten Hoffmann; Leona Wagner; Michael Wermann; Ulrich Heiser; Reiner Kiefersauer; Robert Huber; Wolfram Bode; Hans-Ulrich Demuth; Hans Brandstetter
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-10       Impact factor: 11.205

10.  Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV.

Authors:  Ralf Thoma; Bernd Löffler; Martine Stihle; Walter Huber; Armin Ruf; Michael Hennig
Journal:  Structure       Date:  2003-08       Impact factor: 5.006
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