Literature DB >> 16511110

Crystallization and preliminary X-ray crystallographic analysis of rat calcineurin B homologous protein 1.

Youichi Naoe1, Kyouhei Arita, Hiroshi Hashimoto, Hiroshi Kanazawa, Mamoru Sato, Toshiyuki Shimizu.   

Abstract

Calcineurin B homologous protein 1 (CHP1), also known as p22, is a calcium-binding protein that plays a role in membrane trafficking and binds to multiple effector proteins, including Na+/H+ exchangers, serine/threonine protein kinase and calcineurin, potentially modulating their function. CHP1 has been crystallized at 277 K using polyethylene glycol as a precipitant. The crystal belongs to space group P2(1), with unit-cell parameters a = 55.5, b = 38.5, c = 90.0 A, beta = 90.7 degrees. A full set of diffraction data was collected to 2.2 A resolution at 100 K using the Photon Factory synchrotron-radiation source.

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Year:  2005        PMID： 16511110      PMCID： PMC1952330          DOI： 10.1107/S1744309105016325

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


  12 in total

1.  Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers.

Authors:  T Pang; X Su; S Wakabayashi; M Shigekawa
Journal:  J Biol Chem       Date:  2001-02-28       Impact factor: 5.157

Review 2.  Na(+)/H(+) exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes.

Authors:  Martin Baumgartner; Hitesh Patel; Diane L Barber
Journal:  Am J Physiol Cell Physiol       Date:  2004-10       Impact factor: 4.249

3.  Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein.

Authors:  X Lin; R A Sikkink; F Rusnak; D L Barber
Journal:  J Biol Chem       Date:  1999-12-17       Impact factor: 5.157

4.  Processing of X-ray diffraction data collected in oscillation mode.

Authors:  Z Otwinowski; W Minor
Journal:  Methods Enzymol       Date:  1997       Impact factor: 1.600

5.  Solvent content of protein crystals.

Authors:  B W Matthews
Journal:  J Mol Biol       Date:  1968-04-28       Impact factor: 5.469

6.  Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.

Authors:  C R Kissinger; H E Parge; D R Knighton; C T Lewis; L A Pelletier; A Tempczyk; V J Kalish; K D Tucker; R E Showalter; E W Moomaw
Journal:  Nature       Date:  1995-12-07       Impact factor: 49.962

7.  A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger.

Authors:  M Matsumoto; Y Miyake; M Nagita; H Inoue; D Shitakubo; K Takemoto; C Ohtsuka; H Murakami; N Nakamura; H Kanazawa
Journal:  J Biochem       Date:  2001-08       Impact factor: 3.387

8.  KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles.

Authors:  Norihiro Nakamura; Yoshihide Miyake; Masafumi Matsushita; Shingo Tanaka; Hiroki Inoue; Hiroshi Kanazawa
Journal:  J Biochem       Date:  2002-09       Impact factor: 3.387

9.  The apoptosis-inducing protein kinase DRAK2 is inhibited in a calcium-dependent manner by the calcium-binding protein CHP.

Authors:  Hiroshi Kuwahara; Jun-ichi Kamei; Norihiro Nakamura; Miho Matsumoto; Hiroki Inoue; Hiroshi Kanazawa
Journal:  J Biochem       Date:  2003-08       Impact factor: 3.387

10.  Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elements.

Authors:  Tianxiang Pang; Takashi Hisamitsu; Hidezo Mori; Munekazu Shigekawa; Shigeo Wakabayashi
Journal:  Biochemistry       Date:  2004-03-30       Impact factor: 3.162
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