| Literature DB >> 16510289 |
P Narender1, U Srinivas, M Ravinder, B Ananda Rao, Ch Ramesh, K Harakishore, B Gangadasu, U S N Murthy, V Jayathirtha Rao.
Abstract
Baylis-Hillman acetates were synthesized from substituted 2-chloronicotinaldehydes and were conveniently transformed into multisubstituted quinolines and cyclopenta[g]quinolines on reaction with nitroethane or ethyl cyanoacetate via a successive S(N)2'-S(N)Ar elimination strategy. Thus, synthesized quinolines were evaluated for antimicrobial activity and found having substantial antibacterial and antifungal activity.Entities:
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Year: 2006 PMID： 16510289 DOI： 10.1016/j.bmc.2006.02.020
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641