| Literature DB >> 16510266 |
Charles R Conway1, Yvette I Sheline, John T Chibnall, Mark S George, James W Fletcher, Mark A Mintun.
Abstract
Positron emission tomography (PET oxygen-15 labeled water or PET [15O]H2O) was used to identify changes in regional cerebral blood flow (rCBF) in response to acute vagus nerve stimulation (VNS) in four subjects with treatment-resistant major depression (TRMD). Four 90-s PET [15O]H2O scans were performed on each subject in an off-on sequence (2 VNS de-activated; 2 VNS activated). PET images were aligned, normalized for global uptake, and resampled to standard atlas space. Statistical t-images were used to evaluate change. VNS-induced increases in rCBF were found in the bilateral orbitofrontal cortex, bilateral anterior cingulate cortex, and right superior and medial frontal cortex. Decreases were found in the bilateral temporal cortex and right parietal area. Regions of change were consistent with brain structures associated with depression and the afferent pathways of the vagus nerve.Entities:
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Year: 2006 PMID： 16510266 DOI： 10.1016/j.pscychresns.2005.12.007
Source DB: PubMed Journal: Psychiatry Res ISSN： 0165-1781 Impact factor: 3.222