BACKGROUND: Most patients with colorectal carcinoma will develop liver metastases. Radiofrequency ablation (RFA) has been utilized in metastatic CRC to help improve the survival gap between resectable and unresectable tumor. METHODS: The current use of RFA in selected patient populations is reviewed. RESULTS: RFA provides a survival benefit in patients with unresectable hepatic metastases from CRC compared with chemotherapy alone. It offers effective local tumor destruction in appropriately selected lesions and minimizes the morbidity and mortality of an open resection. Common complications are abdominal bleeding (1.6%), abdominal infection (1.1%), and injury to the biliary tree (1.0%). Mortality ranges from 0% to 0.5%. CONCLUSIONS: Trials are underway to compare chemotherapy plus local ablation to chemotherapy alone. RFA is a tool that should be utilized by experienced individuals to achieve optimal oncologic outcomes.
BACKGROUND: Most patients with colorectal carcinoma will develop liver metastases. Radiofrequency ablation (RFA) has been utilized in metastatic CRC to help improve the survival gap between resectable and unresectable tumor. METHODS: The current use of RFA in selected patient populations is reviewed. RESULTS: RFA provides a survival benefit in patients with unresectable hepatic metastases from CRC compared with chemotherapy alone. It offers effective local tumor destruction in appropriately selected lesions and minimizes the morbidity and mortality of an open resection. Common complications are abdominal bleeding (1.6%), abdominal infection (1.1%), and injury to the biliary tree (1.0%). Mortality ranges from 0% to 0.5%. CONCLUSIONS: Trials are underway to compare chemotherapy plus local ablation to chemotherapy alone. RFA is a tool that should be utilized by experienced individuals to achieve optimal oncologic outcomes.
Authors: Constantinos T Sofocleous; Elena N Petre; Mithat Gonen; Karen T Brown; Stephen B Solomon; Anne M Covey; William Alago; Lynn A Brody; Raymond H Thornton; Michael D'Angelica; Yuman Fong; Nancy E Kemeny Journal: J Vasc Interv Radiol Date: 2011-04-22 Impact factor: 3.464
Authors: Francesco M Polignano; Aaron J Quyn; Pandanaboyana Sanjay; Nikola A Henderson; Iain S Tait Journal: Surg Endosc Date: 2012-03-22 Impact factor: 4.584
Authors: Suzanne Claire Schiffman; Matthew Bower; Russell E Brown; Robert C G Martin; Kelly M McMasters; Charles R Scoggins Journal: J Gastrointest Surg Date: 2010-09-22 Impact factor: 3.452
Authors: Kyung Ho Kim; Yong Sik Yoon; Chang Sik Yu; Tae Won Kim; Hye Jin Kim; Pyo Nyun Kim; Hyun Kwon Ha; Jin Cheon Kim Journal: J Korean Surg Soc Date: 2011-07-11
Authors: Byoung Chul Lee; Hyun Gu Lee; In Ja Park; So Yeon Kim; Ki-Hun Kim; Jae Hoon Lee; Chan Wook Kim; Jong Lyul Lee; Yong Sik Yoon; Seok-Byung Lim; Chang Sik Yu; Jin Cheon Kim Journal: Medicine (Baltimore) Date: 2016-09 Impact factor: 1.889