Literature DB >> 16508195

Synthesis and peptidyl-prolyl isomerase inhibitory activity of quinoxalines as ligands of cyclophilin A.

Feng Wang1, Jing Chen, Xuejun Liu, Xu Shen, Xuchang He, Hualiang Jiang, Donglu Bai.   

Abstract

In search of small molecule compounds as the ligands of cyclophilin A, a series of quinoxalines were prepared, and their K(d) values of cyclophilin A and IC50 values for peptidyl-prolyl isomerase activity of cyclophilin A were tested. The results suggest that some quinoxalines are promising ligands of cyclophilin A.

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Year:  2006        PMID： 16508195     DOI： 10.1248/cpb.54.372

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  4 in total

1.  2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: a structure-activity relationship study.

Authors:  Qianyi Chen; Vashti C Bryant; Hernando Lopez; David L Kelly; Xu Luo; Amarnath Natarajan
Journal:  Bioorg Med Chem Lett       Date:  2011-02-17       Impact factor: 2.823

Review 2.  Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents.

Authors:  Jinhe Han; Myoung Kyu Lee; Yejin Jang; Won-Jea Cho; Meeheyin Kim
Journal:  Drug Discov Today       Date:  2022-05-21       Impact factor: 8.369

3.  Refinement and 3D-QSAR Studies of Inhibitors of Cyclophilin A Containing Amide Linker.

Authors:  Feng Fan; Jin Zhu; Shuaishuai Ni; Jiagao Cheng; Yun Tang; Congmin Kang; Jian Li; Hualiang Jiang
Journal:  QSAR Comb Sci       Date:  2008-11-28

4.  Structure based design, synthesis, pharmacophore modeling, virtual screening, and molecular docking studies for identification of novel cyclophilin D inhibitors.

Authors:  Koteswara Rao Valasani; Jhansi Rani Vangavaragu; Victor W Day; Shirley ShiDu Yan
Journal:  J Chem Inf Model       Date:  2014-02-28       Impact factor: 4.956
  4 in total

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