Literature DB >> 1650816

Immunological evidence for the co-existence of the Lambert-Eaton myasthenic syndrome and myasthenia gravis in two patients.

J Newsom-Davis1, K Leys, A Vincent, I Ferguson, G Modi, K Mills.   

Abstract

Two patients are described in whom a clinical and electromyographic diagnosis of the Lambert-Eaton myasthenic syndrome (LEMS) was made. Serum antibodies to voltage-gated calcium channels (VGCCs), the antigenic target in LEMS and to acetylcholine receptors (AChRs), the antigen in myasthenia gravis, were detected at raised titres in both cases, using radioimmunoassays based on 125I-omega-Conotoxin labelled VGCCs and 125I-alpha-Bungarotoxin labelled AChRs. These data provide immunological evidence for the coexistence of the two disorders in these patients.

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Year:  1991        PMID： 1650816      PMCID： PMC488548          DOI： 10.1136/jnnp.54.5.452

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  9 in total

1.  Increased frequency of IgG heavy chain marker Glm(2) and of HLA-B8 in Lambert-Eaton myasthenic syndrome with and without associated lung carcinoma.

Authors:  N Willcox; A G Demaine; J Newsom-Davis; K I Welsh; S A Robb; S G Spiro
Journal:  Hum Immunol       Date:  1985-09       Impact factor: 2.850

2.  Specificity of calcium channel autoantibodies in Lambert-Eaton myasthenic syndrome.

Authors:  E Sher; C Gotti; N Canal; C Scoppetta; G Piccolo; A Evoli; F Clementi
Journal:  Lancet       Date:  1989-09-16       Impact factor: 79.321

3.  Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis.

Authors:  D A Compston; A Vincent; J Newsom-Davis; J R Batchelor
Journal:  Brain       Date:  1980-09       Impact factor: 13.501

Review 4.  Autoimmunity in neuromuscular disease.

Authors:  J Newsom-Davis
Journal:  Ann N Y Acad Sci       Date:  1988       Impact factor: 5.691

5.  A neuromuscular transmission disorder: combined myasthenia gravis and Lambert Eaton syndrome in one patient.

Authors:  M J Taphoorn; H Van Duijn; E C Wolters
Journal:  J Neurol Neurosurg Psychiatry       Date:  1988-06       Impact factor: 10.154

6.  Trial of low-dose aspirin plus dipyridamole versus anticoagulants for prevention of aortocoronary vein graft occlusion.

Authors:  M Pfisterer; F Burkart; G Jockers; B Meyer; S Regenass; D Burckhardt; H E Schmitt; J Müller-Brand; K Skarvan; P Stulz
Journal:  Lancet       Date:  1989-07-01       Impact factor: 79.321

7.  Autoantibodies bind solubilized calcium channel-omega-conotoxin complexes from small cell lung carcinoma: a diagnostic aid for Lambert-Eaton myasthenic syndrome.

Authors:  V A Lennon; E H Lambert
Journal:  Mayo Clin Proc       Date:  1989-12       Impact factor: 7.616

8.  Acetylcholine receptor antibody as a diagnostic test for myasthenia gravis: results in 153 validated cases and 2967 diagnostic assays.

Authors:  A Vincent; J Newsom-Davis
Journal:  J Neurol Neurosurg Psychiatry       Date:  1985-12       Impact factor: 10.154

9.  The Lambert-Eaton myasthenic syndrome. A review of 50 cases.

Authors:  J H O'Neill; N M Murray; J Newsom-Davis
Journal:  Brain       Date:  1988-06       Impact factor: 13.501
  9 in total
  6 in total

Review 1.  Lambert-Eaton myasthenic syndrome (LEMS): a rare autoimmune presynaptic disorder often associated with cancer.

Authors:  Benedikt Schoser; Bruno Eymard; Joe Datt; Renato Mantegazza
Journal:  J Neurol       Date:  2017-06-12       Impact factor: 4.849

2.  An interesting collection of paraneoplastic syndromes in a patient with a malignant thymoma.

Authors:  Emaddin S Kidher; Natalia Briceno; Ali Taghi; Andrew Chukwuemeka
Journal:  BMJ Case Rep       Date:  2012-07-03

3.  Autonomic dysfunction in Lambert-Eaton myasthenic syndrome.

Authors:  S A Waterman
Journal:  Clin Auton Res       Date:  2001-06       Impact factor: 4.435

4.  A patient with coexisting myasthenia gravis and lambert-eaton myasthenic syndrome.

Authors:  Jee-Ae Kim; Young-Min Lim; Eun Hye Jang; Kwang-Kuk Kim
Journal:  J Clin Neurol       Date:  2012-09-27       Impact factor: 3.077

5.  A case of lambert-eaton myasthenic syndrome with small-cell lung cancer and transient increase in anti-acetylcholine-receptor-binding antibody titer.

Authors:  Jung Hwan Lee; Ha Young Shin; Seung Min Kim; Il Nam Sunwoo
Journal:  J Clin Neurol       Date:  2012-12-21       Impact factor: 3.077

Review 6.  Mapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous system.

Authors:  Nese Sinmaz; Tina Nguyen; Fiona Tea; Russell C Dale; Fabienne Brilot
Journal:  J Neuroinflammation       Date:  2016-08-30       Impact factor: 8.322
  6 in total

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