Fabrication of micromachined magnetic particle separators for bioseparation in microfluidic systems.

Fabrication of micromachined magnetic particle separators is introduced with an emphasis on magnetic particle-based bioseparation in microfluidic systems. The most attractive aspect of the magnetic separation technique in biochemistry and biotechnology is ease of manipulation of biomolecules, which are immobilized on magnetic particles. Embedded electromagnets in the microfluidic channel are described for on-chip magnetic particle separation for lab-on-a-chip applications. An example of microfluidic systems with a magnetic particle separator and integrated microfluidic components is also presented for rapid magnetic particle-based bioseparation and immunoassay.