BACKGROUND: The purpose of this study was to evaluate the effect of ephedrine and phenylephrine on propofol concentrations and bispectral index during propofol anesthesia. METHODS: General anaesthesia was induced with propofol and was maintained with propofol (4 mg kg-1 h-1) and fentanyl. Vecuronium was used to facilitate the artificial ventilation of the lungs. Patients with systolic blood pressure > 90 mmHg were defined as the control group (n = 16). Patients who had to be treated for larger decreases in arterial blood pressure (systolic blood pressure 60, whereas no patient in the control or phenylephrine groups had bispectral index >60. There were no significant differences in propofol concentrations or cardiac output relative to baseline at 3 or 10 min after the administration of ephedrine or phenylephrine. CONCLUSIONS:Ephedrine increases bispectral index values without decreasing propofol concentrations during general anesthesia.
RCT Entities:
BACKGROUND: The purpose of this study was to evaluate the effect of ephedrine and phenylephrine on propofol concentrations and bispectral index during propofol anesthesia. METHODS: General anaesthesia was induced with propofol and was maintained with propofol (4 mg kg-1 h-1) and fentanyl. Vecuronium was used to facilitate the artificial ventilation of the lungs. Patients with systolic blood pressure > 90 mmHg were defined as the control group (n = 16). Patients who had to be treated for larger decreases in arterial blood pressure (systolic blood pressure 60, whereas no patient in the control or phenylephrine groups had bispectral index >60. There were no significant differences in propofol concentrations or cardiac output relative to baseline at 3 or 10 min after the administration of ephedrine or phenylephrine. CONCLUSIONS:Ephedrine increases bispectral index values without decreasing propofol concentrations during general anesthesia.
Authors: Frances Y Hu; George M Hanna; Wei Han; Feras Mardini; Steven A Thomas; Abraham J Wyner; Max B Kelz Journal: Anesthesiology Date: 2012-11 Impact factor: 7.892
Authors: Hyun Jeong Kwak; Bong Ki Moon; Chang Keun Oh; Young Jin Chang; Hong Soon Kim; Jong Yeop Kim Journal: J Clin Monit Comput Date: 2012-10-30 Impact factor: 2.502