| Literature DB >> 1650703 |
M G Belvisi1, D Stretton, P J Barnes.
Abstract
Guinea-pig trachea possesses an inhibitory (bronchodilator) non-adrenergic, non-cholinergic (i-NANC) innervation associated with cholinergic nerves, which may be mediated, at least in part, by nitric oxide (NO). L-NG-Nitro-arginine methyl ester (L-NAME), an inhibitor of endogenous NO synthesis, enhanced cholinergic responses to electrical field stimulation with no effect on contractile responses to exogenous acetylcholine or excitatory NANC (e-NANC) bronchoconstriction. The effects of L-NAME were reversed by L-arginine but not D-arginine. These results suggest that NO released by nerve stimulation modulates cholinergic neurotransmission in guinea-pig trachea.Entities:
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Year: 1991 PMID： 1650703 DOI： 10.1016/0014-2999(91)90626-2
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432