Literature DB >> 16506953

Ocular drug delivery.

Deepta Ghate1, Henry F Edelhauser.   

Abstract

Drug delivery to the eye is hampered by anatomical factors, including the corneal epithelium, the blood-aqueous barrier and the blood-retinal barrier. This review aims to outline the major routes of ocular drug delivery, including systemic, topical, periocular and intravitreal. The pharmacokinetics, the disadvantages and the clinical relevance of these drug delivery routes have been emphasised. Recent advances in surgical techniques, therapeutic approaches and material sciences have produced exciting new therapies for ocular diseases. The role of ophthalmic drug formulation in targeting the desired ocular tissue and enhancing drug delivery by the chosen route whilst minimising side effects is also discussed.

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Year:  2006        PMID： 16506953     DOI： 10.1517/17425247.3.2.275

Source DB:  PubMed          Journal:  Expert Opin Drug Deliv        ISSN： 1742-5247            Impact factor:   6.648


  67 in total

1.  Targeted administration into the suprachoroidal space using a microneedle for drug delivery to the posterior segment of the eye.

Authors:  Samirkumar R Patel; Damian E Berezovsky; Bernard E McCarey; Vladimir Zarnitsyn; Henry F Edelhauser; Mark R Prausnitz
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-07-01       Impact factor: 4.799

Review 2.  Biodegradable implants for sustained drug release in the eye.

Authors:  Susan S Lee; Patrick Hughes; Aron D Ross; Michael R Robinson
Journal:  Pharm Res       Date:  2010-06-10       Impact factor: 4.200

Review 3.  Ocular drug delivery.

Authors:  Ripal Gaudana; Hari Krishna Ananthula; Ashwin Parenky; Ashim K Mitra
Journal:  AAPS J       Date:  2010-05-01       Impact factor: 4.009

Review 4.  Emerging therapeutic approaches in the management of retinal angiogenesis and edema.

Authors:  An Truong; Tien Y Wong; Levon M Khachigian
Journal:  J Mol Med (Berl)       Date:  2010-12-18       Impact factor: 4.599

5.  Ophthalmic drug delivery systems for the treatment of retinal diseases: basic research to clinical applications.

Authors:  Henry F Edelhauser; Cheryl L Rowe-Rendleman; Michael R Robinson; Daniel G Dawson; Gerald J Chader; Hans E Grossniklaus; Kay D Rittenhouse; Clive G Wilson; David A Weber; Baruch D Kuppermann; Karl G Csaky; Timothy W Olsen; Uday B Kompella; V Michael Holers; Gregory S Hageman; Brian C Gilger; Peter A Campochiaro; Scott M Whitcup; Wai T Wong
Journal:  Invest Ophthalmol Vis Sci       Date:  2010-11       Impact factor: 4.799

6.  A novel approach to formulation factor of aceclofenac eye drops efficiency evaluation based on physicochemical characteristics of in vitro and in vivo permeation.

Authors:  Vivek Dave; Sarvesh Paliwal
Journal:  Saudi Pharm J       Date:  2013-03-30       Impact factor: 4.330

7.  Microneedle-mediated intrascleral delivery of in situ forming thermoresponsive implants for sustained ocular drug delivery.

Authors:  Raghu Raj Singh Thakur; Steven J Fallows; Hannah L McMillan; Ryan F Donnelly; David S Jones
Journal:  J Pharm Pharmacol       Date:  2013-10-16       Impact factor: 3.765

8.  Mucoadhesive microparticles in a rapidly dissolving tablet for sustained drug delivery to the eye.

Authors:  Young Bin Choy; Samirkumar R Patel; Jung-Hwan Park; Bernard E McCarey; Henry F Edelhauser; Mark R Prausnitz
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-04-22       Impact factor: 4.799

9.  Examination of barriers and barrier alteration in transscleral iontophoresis.

Authors:  Sarah A Molokhia; Eun-Kee Jeong; William I Higuchi; S Kevin Li
Journal:  J Pharm Sci       Date:  2008-02       Impact factor: 3.534

Review 10.  Challenges in the Polyene- and Azole-Based Pharmacotherapy of Ocular Fungal Infections.

Authors:  Prit Lakhani; Akash Patil; Soumyajit Majumdar
Journal:  J Ocul Pharmacol Ther       Date:  2018-11-08       Impact factor: 2.671
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