Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 An alkoxide-directed carbometalation of internal alkynes.

Literature DB >> 16506731

An alkoxide-directed carbometalation of internal alkynes.

Abstract

A mild and efficient alkoxide-directed carbometalation is described. Regioselective carbon-carbon bond formation occurs in all cases at the site distal to the tethered alkoxide. This reaction provides a convenient means to prepare differentially functionalized tetrasubstituted 1,3-dienes in a regio- and stereoselective manner.

Entities: Chemical

Year: 2006 PMID： 16506731 DOI： 10.1021/ja057352w

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

Keyword Cloud
Cited

28 in total

1. Dative Directing Group Effects in Ti-Catalyzed [2+2+1] Pyrrole Synthesis: Chemo- and Regioselective Alkyne Heterocoupling.

Authors: Hsin-Chun Chiu; Xin Yi See; Ian A Tonks
Journal: ACS Catal Date: 2018-11-29 Impact factor: 13.084

2. Iron-catalyzed carbometalation of propargylic and homopropargylic alcohols.

Authors: Donghui Zhang; Joseph M Ready
Journal: J Am Chem Soc Date: 2006-11-29 Impact factor: 15.419

3. Reaction design, discovery, and development as a foundation to function-oriented synthesis.

Authors: Glenn C Micalizio; Sarah B Hale
Journal: Acc Chem Res Date: 2015-02-10 Impact factor: 22.384

4. Regio- and stereoselective cross-coupling of substituted olefins and imines. A convergent stereoselective synthesis of saturated 1,5-amino-alcohols and substituted piperidines.

Authors: Masayuki Takahashi; Glenn C Micalizio
Journal: J Am Chem Soc Date: 2007-05-26 Impact factor: 15.419

5. Synthesis of substituted 1,4-dienes by direct alkylation of allylic alcohols.

Authors: Filip Kolundzic; Glenn C Micalizio
Journal: J Am Chem Soc Date: 2007-11-16 Impact factor: 15.419

6. Recent Progress in Steroid Synthesis Triggered by the Emergence of New Catalytic Methods.

Authors: Hem Raj Khatri; Nolan Carney; Ryan Rutkoski; Bijay Bhattarai; Pavel Nagorny
Journal: European J Org Chem Date: 2020-01-01

7. Synthesis of Angularly Substituted trans-Fused Decalins through a Metallacycle-Mediated Annulative Cross-Coupling Cascade.

Authors: Haruki Mizoguchi; Glenn C Micalizio
Journal: Angew Chem Int Ed Engl Date: 2016-10-10 Impact factor: 15.336