Subacute human spinal cord contusion: few lymphocytes and many macrophages.

STUDY
DESIGN: Clinicopathological correlation of three cases of subacute cervical spinal cord contusions.
OBJECTIVE: To correlate the pathology of subacute cervical spinal cord injury (SCI) with imaging and clinical-functional studies, and to compare with findings from previous human SCI studies and animal models of SCI.
SETTING: Department of Pathology, SUNY-Upstate Medical University, Syracuse, NY, USA.
METHOD: Post mortem pathology report. CASE REPORT/
RESULTS: The clinical, radiological, and pathological findings of three cases of subacute spinal cord contusions are described in detail. The postinjury survival periods were 15, 20, and 60 days, respectively. Extensive microglia/macrophage infiltrations without significant lymphocytes are seen in all cases. Free radical injury as assessed by immunocytochemistry for 4-hydroxynonenal and nitrotyrosine showed a labeling pattern parallel to that of the macrophage distribution at 15 days, but no significant labeling in the injury sites at 20 and 60 days.
CONCLUSION: The present report, though limited in sample size, shows plenty of activated microglia/macrophages in human SCI up to 60 days postinjury. This observation not only confirms similar findings in previous studies, but also raises an intriguing question of potential interactions between these activated microglia/macrophages and the experimental therapy, proposed by some authors, of injecting exogenously activated macrophages to promote SCI repair. The small number of human SCI cases (in this as well as in most other single medical centers) available for detailed study illustrates the need for the establishment of a consortium of human SCI tissue banks.