Literature DB >> 1650521

Drugs effects on superoxide generation and chemiluminescence response of human leukocytes.

C Pascual1, R González, C Romay.   

Abstract

Luminol-enhanced chemiluminescence was used to determine the effects of diethyldithiocarbamate, dipyridamole, catechin and verapamil on the generation of reactive oxygen species in human leukocytes, and on superoxide generated by chemiluminescence of the hypoxanthine xanthine-oxidase reaction. These agents reduced the luminol enhanced chemiluminescence response of activated leukocytes, most probably by inhibiting the superoxide generation reaction. On the other hand, citrate and diethylcarbamazine, produced a slight increase of the luminol enhanced chemiluminescence of leukocytes.

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Year:  1991        PMID： 1650521     DOI： 10.1007/bf01980886

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  13 in total

1.  Diethyldithiocarbamate inhibits scheduled and unscheduled DNA synthesis of rat thymocytes in vitro and in vivo--dose-effect relationships and mechanisms of action.

Authors:  A Spath; K Tempel
Journal:  Chem Biol Interact       Date:  1987       Impact factor: 5.192

2.  Role of hydrogen peroxide in the cytotoxicity of the xanthine/xanthine oxidase system.

Authors:  E M Link; P A Riley
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857

3.  Dipyridamole inhibits leukotriene B4 synthesis.

Authors:  P Gresele; J Arnout; J Vermylen
Journal:  Thromb Haemost       Date:  1987-04-07       Impact factor: 5.249

4.  Kinetics of adenosine uptake by erythrocytes, and the influence of dipyridamole.

Authors:  H Roos; K Pfleger
Journal:  Mol Pharmacol       Date:  1972-07       Impact factor: 4.436

Review 5.  On the antioxidant hypothesis with regard to arteriosclerosis.

Authors:  K F Gey
Journal:  Bibl Nutr Dieta       Date:  1986

Review 6.  Free radicals and anti-inflammatory drugs.

Authors:  H Vapaatalo
Journal:  Med Biol       Date:  1986

7.  Variables in xanthine oxidase-initiated luminol chemiluminescence: implications for chemiluminescence measurements in biological systems.

Authors:  J Wilhelm; V Vilím
Journal:  Anal Biochem       Date:  1986-10       Impact factor: 3.365

8.  Trial of (+)-cyanidanol-3 in patients with hepatitis B chronic liver disease.

Authors:  P W Keeling; L Viola; M G Anderson; J H Marigold; J C Macartney; F J Paradinas; I M Murray-Lyon; R P Thompson
Journal:  J R Soc Med       Date:  1986-08       Impact factor: 5.344

9.  A new screening system for nonsteroidal anti-inflammatory drugs based upon inhibition of chemiluminescence produced from human cells (granulocytes).

Authors:  K Van Dyke; C Van Dyke; J Udeinya; C Brister; M Wilson
Journal:  Clin Chem       Date:  1979-09       Impact factor: 8.327

10.  PHA- and Con A-induced chemiluminescence of human blood mononuclear cells and granulocytes in luminol or lucigenin.

Authors:  K Merétey; M Antal; Z Rozsnyay; U Böhm; E Elekes; G Genti
Journal:  Inflammation       Date:  1987-12       Impact factor: 4.092
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