Literature DB >> 1650444

Alterations at the rel locus in human lymphoma.

D Lu1, J D Thompson, G K Gorski, N R Rice, M G Mayer, J J Yunis.   

Abstract

The rel proto-oncogene has been mapped to chromosome region 2p11.2-14, a site associated with nonrandom rearrangements in non-Hodgkin's lymphoma. We have characterized an abnormal rel mRNA from a cell line derived from a diffuse large cell lymphoma, in which the evolutionarily conserved N-terminal half of the rel coding region was fused with the C-terminal coding region of an unrelated gene. In addition, rearrangement or amplification of the rel locus was found in the lymphomatous tissue of two follicular and one diffuse large cell lymphoma. The findings suggest involvement of rel in the pathogenesis of large cell lymphoma.

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Year:  1991        PMID： 1650444

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  22 in total

1.  Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3.

Authors:  D Lu; J J Yunis
Journal:  Nucleic Acids Res       Date:  1992-04-25       Impact factor: 16.971

2.  Interaction of the v-Rel oncoprotein with NF-kappaB and IkappaB proteins: heterodimers of a transformation-defective v-Rel mutant and NF-2 are functional in vitro and in vivo.

Authors:  D W White; G A Pitoc; T D Gilmore
Journal:  Mol Cell Biol       Date:  1996-03       Impact factor: 4.272

3.  The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).

Authors:  C Chen; L C Edelstein; C Gélinas
Journal:  Mol Cell Biol       Date:  2000-04       Impact factor: 4.272

4.  The c-Rel Transcription Factor in Development and Disease.

Authors:  Thomas D Gilmore; Steve Gerondakis
Journal:  Genes Cancer       Date:  2011-07

5.  A rearranged EP300 gene in the human B-cell lymphoma cell line RC-K8 encodes a disabled transcriptional co-activator that contributes to cell growth and oncogenicity.

Authors:  Michael R Garbati; Ryan C Thompson; Leila Haery; Thomas D Gilmore
Journal:  Cancer Lett       Date:  2011-01-12       Impact factor: 8.679

6.  The relocalization of v-Rel from the nucleus to the cytoplasm coincides with induction of expression of Ikba and nfkb1 and stabilization of I kappa B-alpha.

Authors:  R Hrdlicková; J Nehyba; A Roy; E H Humphries; H R Bose
Journal:  J Virol       Date:  1995-01       Impact factor: 5.103

7.  Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8.

Authors:  Michael R Garbati; Gökçen Alço; Thomas D Gilmore
Journal:  Cancer Lett       Date:  2009-11-30       Impact factor: 8.679

Review 8.  Intercellular adhesion molecule-1.

Authors:  A van de Stolpe; P T van der Saag
Journal:  J Mol Med (Berl)       Date:  1996-01       Impact factor: 4.599

9.  PEST-dependent cytoplasmic retention of v-Rel by I(kappa)B-alpha: evidence that I(kappa)B-alpha regulates cellular localization of c-Rel and v-Rel by distinct mechanisms.

Authors:  E M Rottjakob; S Sachdev; C A Leanna; T A McKinsey; M Hannink
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103

10.  v-rel induces expression of three avian immunoregulatory surface receptors more efficiently than c-rel.

Authors:  R Hrdlicková; J Nehyba; E H Humphries
Journal:  J Virol       Date:  1994-01       Impact factor: 5.103
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