Literature DB >> 16503731

The role of Toll-like receptors in immune disorders.

Satoshi Uematsu1, Shizuo Akira.   

Abstract

Toll-like receptors (TLRs) play an important role in innate immunity. Individual TLRs recognise microbial components that are conserved among pathogens. Such recognition initiates necessary inflammatory immune responses and induces subsequent activation of adaptive immunity. Studies in people with polymorphisms in genes encoding TLR signalling can elucidate the relationship between TLRs and human diseases, such as infectious diseases, atherosclerosis and immunodeficiency. Indeed, accumulating data in respect to TLR signalling suggest that TLRs are closely related with the pathogenesis of autoimmune diseases. This review looks at the role of TLRs in various immune disorders, and discusses the pathogenesis of diseases.

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Year:  2006        PMID： 16503731     DOI： 10.1517/14712598.6.3.203

Source DB:  PubMed          Journal:  Expert Opin Biol Ther        ISSN： 1471-2598            Impact factor:   4.388


  15 in total

1.  NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice.

Authors:  Rongbin Zhou; Haiming Wei; Rui Sun; Jian Zhang; Zhigang Tian
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-26       Impact factor: 11.205

Review 2.  Toll gates to periodontal host modulation and vaccine therapy.

Authors:  George Hajishengallis
Journal:  Periodontol 2000       Date:  2009       Impact factor: 7.589

3.  Variation in the Ovine Abomasal Lymph Node Transcriptome between Breeds Known to Differ in Resistance to the Gastrointestinal Nematode.

Authors:  Albin M Ahmed; Barbara Good; James P Hanrahan; Paul McGettigan; John Browne; Orla M Keane; Bojlul Bahar; Jai Mehta; Bryan Markey; Amanda Lohan; Torres Sweeney
Journal:  PLoS One       Date:  2015-05-15       Impact factor: 3.240

4.  Selenium Deficiency via the TLR4/TRIF/NF-κB Signaling Pathway Leading to Inflammatory Injury in Chicken Spleen.

Authors:  Ruili Zhang; Rong Guo; Qing Liu; Guangxing Li; Bin Sun; Xiaodan Huang
Journal:  Biol Trace Elem Res       Date:  2020-05-09       Impact factor: 3.738

Review 5.  Microbe-dendritic cell dialog controls regulatory T-cell fate.

Authors:  John R Grainger; Jason A Hall; Nicolas Bouladoux; Guillaume Oldenhove; Yasmine Belkaid
Journal:  Immunol Rev       Date:  2010-03       Impact factor: 12.988

6.  Toll-like receptor 2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population.

Authors:  Mayuki Sato; Tatsukata Kawagoe; Akira Meguro; Masao Ota; Yoshihiko Katsuyama; Mami Ishihara; Kenichi Namba; Nobuyoshi Kitaichi; Shin-ichiro Morimoto; Toshikatsu Kaburaki; Yasutaka Ando; Shinobu Takenaka; Shigeaki Ohno; Hidetoshi Inoko; Nobuhisa Mizuki
Journal:  Mol Vis       Date:  2011-03-15       Impact factor: 2.367

7.  Generation of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation.

Authors:  Carsten J Kirschning; Stefan Dreher; Björn Maass; Sylvia Fichte; Jutta Schade; Mario Köster; Andreas Noack; Werner Lindenmaier; Hermann Wagner; Thomas Böldicke
Journal:  BMC Biotechnol       Date:  2010-04-13       Impact factor: 2.563

Review 8.  Toll-like receptors expression and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic application.

Authors:  Dorit Trudler; Dorit Farfara; Dan Frenkel
Journal:  Mediators Inflamm       Date:  2010-07-25       Impact factor: 4.711

9.  Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses.

Authors:  Jason A Hall; Nicolas Bouladoux; Cheng Ming Sun; Elizabeth A Wohlfert; Rebecca B Blank; Qing Zhu; Michael E Grigg; Jay A Berzofsky; Yasmine Belkaid
Journal:  Immunity       Date:  2008-10-02       Impact factor: 31.745

Review 10.  Oral Versus Gastrointestinal Mucosal Immune Niches in Homeostasis and Allostasis.

Authors:  Lina J Suárez; Silie Arboleda; Nikola Angelov; Roger M Arce
Journal:  Front Immunol       Date:  2021-07-05       Impact factor: 7.561
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