| Literature DB >> 16503140 |
Fateh V Singh1, Rit Vatsyayan, Uma Roy, Atul Goel.
Abstract
A series of anthranilodinitrile-based biaryls were synthesized and evaluated in vitro against extracellular promastigotes and intracellular amastigotes of Leishmania donovani. Among various screened compounds, a biaryl with trifluoromethyl group 5f showed 83% inhibition against promastigotes and 70% inhibition against amastigotes of L. donovani at 8 and 20microg/mL concentrations, respectively.Entities:
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Year: 2006 PMID： 16503140 DOI： 10.1016/j.bmcl.2006.02.012
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823