Literature DB >> 1650279

Potent blocking action of lead on voltage-activated calcium channels in human neuroblastoma cells SH-SY5Y.

E Reuveny1, T Narahashi.   

Abstract

Human neuroblastoma cells (SH-SY5Y) have two types of voltage-activated calcium channels, which are equivalent to the N and L types. Both types of calcium channels were equally blocked by lead in a concentration-dependent and reversible manner, with Ki congruent to 1 microM. This lead concentration is in the same order of magnitude as that found in the blood of children exhibiting neuropsychological disorders. Sodium and potassium channel currents were not significantly affected by lead at a concentration of 10 microM.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1650279     DOI： 10.1016/0006-8993(91)91304-j

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

Review 1.  Effects of toxic environmental contaminants on voltage-gated calcium channel function: from past to present.

Authors:  William D Atchison
Journal:  J Bioenerg Biomembr       Date:  2003-12       Impact factor: 2.945

2.  Effects of lead on cloned voltage-operated neuronal potassium channels.

Authors:  M Madeja; N Binding; U Musshoff; O Pongs; U Witting; E J Speckmann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-03       Impact factor: 3.000

3.  Long-term potentiation in the piriform cortex is blocked by lead.

Authors:  D O Carpenter; M R Matthews; P J Parsons; N Hori
Journal:  Cell Mol Neurobiol       Date:  1994-12       Impact factor: 5.046

4.  Lead-induced alterations of apoptosis and neurotrophic factor mRNA in the developing rat cortex, hippocampus, and cerebellum.

Authors:  Shirley L Chao; Jason M Moss; G Jean Harry
Journal:  J Biochem Mol Toxicol       Date:  2007       Impact factor: 3.642

5.  Low lead levels stunt neuronal growth in a reversible manner.

Authors:  H T Cline; S Witte; K W Jones
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-03       Impact factor: 11.205

6.  Metal toxicity at the synapse: presynaptic, postsynaptic, and long-term effects.

Authors:  Sanah Sadiq; Zena Ghazala; Arnab Chowdhury; Dietrich Büsselberg
Journal:  J Toxicol       Date:  2012-01-12

Review 7.  Neuroimmunotoxicology: humoral assessment of neurotoxicity and autoimmune mechanisms.

Authors:  H A El-Fawal; S J Waterman; A De Feo; M Y Shamy
Journal:  Environ Health Perspect       Date:  1999-10       Impact factor: 9.031

8.  Metal interactions with voltage- and receptor-activated ion channels.

Authors:  H P Vijverberg; M Oortgiesen; T Leinders; R G van Kleef
Journal:  Environ Health Perspect       Date:  1994-09       Impact factor: 9.031
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.