Angus Forbes1, Alison While, Lucia Mathes, Peter Griffiths. 1. King's College London, The Florence Nightingale School of Nursing & Midwifery, Research in Primary and Intermediate Care Section, London, UK. angus.forbes@kcl.ac.uk
Abstract
OBJECTIVE: To explore the interrelationship between a number of common multiple sclerosis-related problems and health-related quality of life independent of the effect of physical disease impact. DESIGN: A cross-sectional postal survey. SETTING: The study was conducted in seven treatment centres within England. SUBJECTS: Nine hundred and twenty-nine people with multiple sclerosis. MEASURES: The severity of the multiple sclerosis problems (fatigue, pain, urinary incontinence, bowel, depression, pressure ulcers, sexual and employment problems) was assessed using 5-point self-report ordinal scales. Disease impact was measured using the Multiple Sclerosis Impact Scale-29. Health-related quality of life was measured using the 36-Item Short Form Health Survey, version 2 (SF-36). The relationship between the problems, disease impact and health-related quality of life was determined using multivariate analysis of covariance. RESULTS: Seventy four per cent of the sample experienced four or more of the selected problems. The extent and severity of problems increased with the level of disease impact (P< 0.001). Fatigue, pain, employment, depression and relationship problems were all found to have negative effect on the SF-36 scales independent to the effect of disease impact. SF-36 scores were most compromised in patients experiencing multiple problems. The data suggest an interdependent relationship between depression, fatigue and pain. CONCLUSION: The data suggest that many multiple sclerosis complications negatively affect health-related quality of life, independent of the effect of overall disease impact.
OBJECTIVE: To explore the interrelationship between a number of common multiple sclerosis-related problems and health-related quality of life independent of the effect of physical disease impact. DESIGN: A cross-sectional postal survey. SETTING: The study was conducted in seven treatment centres within England. SUBJECTS: Nine hundred and twenty-nine people with multiple sclerosis. MEASURES: The severity of the multiple sclerosis problems (fatigue, pain, urinary incontinence, bowel, depression, pressure ulcers, sexual and employment problems) was assessed using 5-point self-report ordinal scales. Disease impact was measured using the Multiple Sclerosis Impact Scale-29. Health-related quality of life was measured using the 36-Item Short Form Health Survey, version 2 (SF-36). The relationship between the problems, disease impact and health-related quality of life was determined using multivariate analysis of covariance. RESULTS: Seventy four per cent of the sample experienced four or more of the selected problems. The extent and severity of problems increased with the level of disease impact (P< 0.001). Fatigue, pain, employment, depression and relationship problems were all found to have negative effect on the SF-36 scales independent to the effect of disease impact. SF-36 scores were most compromised in patients experiencing multiple problems. The data suggest an interdependent relationship between depression, fatigue and pain. CONCLUSION: The data suggest that many multiple sclerosis complications negatively affect health-related quality of life, independent of the effect of overall disease impact.
Authors: Lisa M Jaremka; Rebecca R Andridge; Christopher P Fagundes; Catherine M Alfano; Stephen P Povoski; Adele M Lipari; Doreen M Agnese; Mark W Arnold; William B Farrar; Lisa D Yee; William E Carson; Tanios Bekaii-Saab; Edward W Martin; Carl R Schmidt; Janice K Kiecolt-Glaser Journal: Health Psychol Date: 2013-08-19 Impact factor: 4.267
Authors: Michela Ponzio; Andrea Tacchino; Paola Zaratin; Concetta Vaccaro; Mario Alberto Battaglia Journal: Eur J Public Health Date: 2015-03-30 Impact factor: 3.367
Authors: Shahnaz Shahrbanian; Mohammad Auais; Pierre Duquette; Katie Andersen; Katie Anderson; Nancy E Mayo Journal: Pain Res Manag Date: 2013 Sep-Oct Impact factor: 3.037
Authors: Nora E Fritz; Snehashis Roy; Jennifer Keller; Jerry Prince; Peter A Calabresi; Kathleen M Zackowski Journal: NeuroRehabilitation Date: 2016-10-14 Impact factor: 2.138