Literature DB >> 16502344

IL-18 receptor expression on epithelial cells is upregulated by TNF alpha.

Eliska Krásná1, Libor Kolesár, Antonij Slavcev, Sárka Valhová, Bohumíra Kronosová, Marcela Jaresová, Ilja Stríz.   

Abstract

IL-18 is a multifunctional cytokine that augments both innate and acquired immunity and potentiates Th1 and Th2 reactions. We studied the expression of IL-18 receptor (IL-18R) on renal and respiratory epithelial cell lines. Both cell lines upregulated IL-18R mRNA and IL-18R membrane expression in response to TNF alpha and other proinflammatory cytokines. The function of IL-18R was confirmed by induction of IL-8 release from epithelial cells in response to recombinant IL-18. Epithelial cells may represent an important target for IL-18, mainly under inflammatory conditions associated with TNF alpha release.

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Year:  2005        PMID： 16502344     DOI： 10.1007/s10753-006-8967-1

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  21 in total

1.  Serum interferon-gamma-inducing factor/IL-18 levels in primary biliary cirrhosis.

Authors:  T Yamano; T Higashi; K Nouso; H Nakatsukasa; K Kariyama; E Yumoto; Y Kobayashi; K Yamamoto; H Iwagaki; T Yagi; T Tanimoto; M Kurimoto; N Tanaka; T Tsuji
Journal:  Clin Exp Immunol       Date:  2000-11       Impact factor: 4.330

Review 2.  IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family.

Authors:  C A Dinarello
Journal:  J Allergy Clin Immunol       Date:  1999-01       Impact factor: 10.793

3.  IL-18 production in human pulmonary and pleural tuberculosis.

Authors:  C-H Song; J-S Lee; H-H Nam; J-M Kim; J-W Suhr; S-S Jung; M-J Na; T-H Paik; H-J Kim; J-K Park; E-K Jo
Journal:  Scand J Immunol       Date:  2002-12       Impact factor: 3.487

4.  Airway epithelium expresses interleukin-18.

Authors:  L A Cameron; R A Taha; A Tsicopoulos; M Kurimoto; R Olivenstein; B Wallaert; E M Minshall; Q A Hamid
Journal:  Eur Respir J       Date:  1999-09       Impact factor: 16.671

5.  IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells.

Authors:  T T Pizarro; M H Michie; M Bentz; J Woraratanadharm; M F Smith; E Foley; C A Moskaluk; S J Bickston; F Cominelli
Journal:  J Immunol       Date:  1999-06-01       Impact factor: 5.422

6.  Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation.

Authors:  Marc De Perrot; Yasuo Sekine; Stefan Fischer; Thomas K Waddell; Karen McRae; Mingyao Liu; Dennis A Wigle; Shaf Keshavjee
Journal:  Am J Respir Crit Care Med       Date:  2002-01-15       Impact factor: 21.405

7.  Relationship between IL-18 and sICAM-1 serum levels in patients affected by coeliac disease: preliminary considerations.

Authors:  Rosaria Alba Merendino; Giuseppe Di Pasquale; Giacomo Carlo Sturniolo; Antonella Ruello; Vincenzo Albanese; Paola Lucia Minciullo; Sebastiano Di Mauro; Sebastiano Gangemi
Journal:  Immunol Lett       Date:  2003-02-03       Impact factor: 3.685

8.  Expression of Interleukin-18, a Th1 cytokine, in human gastric mucosa is increased in Helicobacter pylori infection.

Authors:  T Tomita; A M Jackson; N Hida; M Hayat; M F Dixon; T Shimoyama; A T Axon; P A Robinson; J E Crabtree
Journal:  J Infect Dis       Date:  2001-01-24       Impact factor: 5.226

9.  Role of IL-18 in CD4+ T lymphocyte activation in sarcoidosis.

Authors:  C M Greene; G Meachery; C C Taggart; C P Rooney; R Coakley; S J O'Neill; N G McElvaney
Journal:  J Immunol       Date:  2000-10-15       Impact factor: 5.422

10.  Neutrophil-independent mechanisms of caspase-1- and IL-18-mediated ischemic acute tubular necrosis in mice.

Authors:  Vyacheslav Y Melnikov; Sarah Faubel; Britta Siegmund; M Scott Lucia; Danica Ljubanovic; Charles L Edelstein
Journal:  J Clin Invest       Date:  2002-10       Impact factor: 14.808
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  6 in total

1.  Epigenetic and inflammatory events in experimental periodontitis following systemic microbial challenge.

Authors:  Daniela B Palioto; Livia S Finoti; Denis F Kinane; Manjunatha Benakanakere
Journal:  J Clin Periodontol       Date:  2019-06-25       Impact factor: 8.728

2.  Strain differences influence murine pulmonary responses to Stachybotrys chartarum.

Authors:  Jamie H Rosenblum Lichtenstein; Ramon M Molina; Thomas C Donaghey; Joseph D Brain
Journal:  Am J Respir Cell Mol Biol       Date:  2006-05-11       Impact factor: 6.914

3.  Intermediary Role of Lung Alveolar Type 1 Cells in Epithelial Repair upon Sendai Virus Infection.

Authors:  Belinda J Hernandez; Margo P Cain; Anne M Lynch; Jose R Flores; Michael J Tuvim; Burton F Dickey; Jichao Chen
Journal:  Am J Respir Cell Mol Biol       Date:  2022-09       Impact factor: 7.748

4.  Increased adipose tissue expression of IL-18R and its ligand IL-18 associates with inflammation and insulin resistance in obesity.

Authors:  Rasheed Ahmad; Reeby Thomas; Shihab Kochumon; Sardar Sindhu
Journal:  Immun Inflamm Dis       Date:  2017-05-15

5.  Association between IL-18/18R gene polymorphisms and coronary artery disease: influence of IL-18/18R genetic variants on cytokine expression.

Authors:  Vadim Mitrokhin; Alexey Nikitin; Olga Brovkina; Dmitry Khodyrev; Alexander Zotov; Nikita Vachrushev; Dmitry Dragunov; Andrey Shim; Mitko Mladenov; Andre Kamkin
Journal:  J Inflamm Res       Date:  2018-01-18

6.  New immunological potential markers for triple negative breast cancer: IL18R1, CD53, TRIM, Jaw1, LTB, PTPRCAP.

Authors:  Paolo Marchetti; Alexey Antonov; Lucia Anemona; Chaitania Vangapandou; Manuela Montanaro; Andrea Botticelli; Alessandro Mauriello; Gerry Melino; M Valeria Catani
Journal:  Discov Oncol       Date:  2021-03-10
  6 in total

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