Literature DB >> 1650187

A DNA topoisomerase I inhibitor blocks the differentiation of rat granulosa cells induced by follicle-stimulating hormone.

J L Barañao1, M A Bley, F D Batista, G C Glikin.   

Abstract

Follicle-stimulating hormone (FSH), acting through a cycle AMP-mediated mechanism, promotes differentiation of rat granulosa cells cultured in a defined medium. Camptothecin, a DNA topoisomerase I blocker, inhibited the increase in progesterone and oestradiol production stimulated by FSH. This effect was not due to non-specific inhibition of protein synthesis, as shown by measurement of [35S]methionine incorporation. A transient increase in DNA topoisomerase I activity was observed after 24 h of culture in the presence of FSH or dibutyryl cyclic AMP. Our results are consistent with a key role for DNA topoisomerase I in the modulation of gene expression by FSH in rat granulosa cells.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1650187      PMCID： PMC1151270          DOI： 10.1042/bj2770557

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  27 in total

1.  DNA topoisomerase I from Leydig cells is modulated by luteinizing hormone and cyclic adenosine monophosphate.

Authors:  M D Crespi; J P Radicella; A Baldi; E H Charreau; J C Calvo
Journal:  Mol Cell Endocrinol       Date:  1987-10       Impact factor: 4.102

2.  FSH increases the synthesis and stores of cholesterol in porcine granulosa cells.

Authors:  J L Barañao; J M Hammond
Journal:  Mol Cell Endocrinol       Date:  1986-03       Impact factor: 4.102

Review 3.  DNA topoisomerases.

Authors:  J C Wang
Journal:  Annu Rev Biochem       Date:  1985       Impact factor: 23.643

4.  Microinjection of anti-topoisomerase I immunoglobulin G into nuclei of Chironomus tentans salivary gland cells leads to blockage of transcription elongation.

Authors:  E Egyházi; E Durban
Journal:  Mol Cell Biol       Date:  1987-12       Impact factor: 4.272

Review 5.  Cyclic AMP and the induction of eukaryotic gene transcription.

Authors:  W J Roesler; G R Vandenbark; R W Hanson
Journal:  J Biol Chem       Date:  1988-07-05       Impact factor: 5.157

6.  Role of DNA topoisomerase I in the transcription of supercoiled rRNA gene.

Authors:  L C Garg; S DiAngelo; S T Jacob
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

7.  Localization of specific topoisomerase I interactions within the transcribed region of active heat shock genes by using the inhibitor camptothecin.

Authors:  D S Gilmour; S C Elgin
Journal:  Mol Cell Biol       Date:  1987-01       Impact factor: 4.272

8.  A high affinity topoisomerase I binding sequence is clustered at DNAase I hypersensitive sites in Tetrahymena R-chromatin.

Authors:  B J Bonven; E Gocke; O Westergaard
Journal:  Cell       Date:  1985-06       Impact factor: 41.582

9.  Topoisomerase I interacts with transcribed regions in Drosophila cells.

Authors:  D S Gilmour; G Pflugfelder; J C Wang; J T Lis
Journal:  Cell       Date:  1986-02-14       Impact factor: 41.582

10.  Inhibitors of topoisomerases I and II arrest DNA replication, but do not prevent nucleosome assembly in vivo.

Authors:  A T Annunziato
Journal:  J Cell Sci       Date:  1989-08       Impact factor: 5.285
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.