Literature DB >> 16500245

Predictors of mortality in close proximity blast injuries during Operation Iraqi Freedom.

Thomas J Nelson1, Derek B Wall, Eric T Stedje-Larsen, Richard T Clark, Lowell W Chambers, Harold R Bohman.   

Abstract

BACKGROUND: Blast injury is an increasingly common problem faced by military surgeons in the field. Because of urban terrorism worldwide, blast injury is becoming more common in the civilian sector as well. Blast injuries are often devastating and can overwhelm medical resources. We sought to determine whether simple factors easily obtained from the clinical history and primary survey could be used to triage patients more effectively. STUDY
DESIGN: A retrospective review of 18 consecutive close-proximity blast injury patients presenting to a forward deployed surgical unit in Iraq was performed. Patients' injuries and outcomes were recorded. We compared the presence of sustained hypotension, penetrating head injury, multiple (three or more) long-bone fractures, and associated fatalities (whether another patient involved in the same explosion died) between nonsurvivors and survivors using Fisher's exact test.
RESULTS: All patients who presented alive but exhibited sustained hypotension (n = 5) died, versus 0% who did not exhibit sustained hypotension (n = 9, p < 0.01). There was no marked increase in mortality with presence of multiple long-bone fractures, penetrating head injury, or associated fatalities individually. Having two or more of these factors was associated with a mortality of 86% (6 of 7) versus 20% (2 of 10, p = 0.015) in those who had less than two factors.
CONCLUSIONS: Blast injury can overwhelm military and civilian trauma systems alike. Sustained hypotension and presence of two or more easily determined factors, including three or more long-bone fractures, penetrating head injury, and associated fatalities, are associated with increased mortality and can potentially help triage patients and allocate scarce resources more efficiently.

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Year:  2006        PMID: 16500245     DOI: 10.1016/j.jamcollsurg.2005.11.011

Source DB:  PubMed          Journal:  J Am Coll Surg        ISSN: 1072-7515            Impact factor:   6.113


  14 in total

Review 1.  The epidemiology of blast lung injury during recent military conflicts: a retrospective database review of cases presenting to deployed military hospitals, 2003-2009.

Authors:  J E Smith
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2011-01-27       Impact factor: 6.237

2.  Polynitroxylated-pegylated hemoglobin attenuates fluid requirements and brain edema in combined traumatic brain injury plus hemorrhagic shock in mice.

Authors:  Erik C Brockman; Hülya Bayır; Brian Blasiole; Steven L Shein; Ericka L Fink; Cedward Dixon; Robert S B Clark; Vincent A Vagni; Li Ma; Carleton J C Hsia; Samuel A Tisherman; Patrick M Kochanek
Journal:  J Cereb Blood Flow Metab       Date:  2013-06-26       Impact factor: 6.200

3.  Severe brief pressure-controlled hemorrhagic shock after traumatic brain injury exacerbates functional deficits and long-term neuropathological damage in mice.

Authors:  Joseph N Hemerka; Xianren Wu; C Edward Dixon; Robert H Garman; Jennifer L Exo; David K Shellington; Brian Blasiole; Vincent A Vagni; Keri Janesko-Feldman; Mu Xu; Stephen R Wisniewski; Hülya Bayır; Larry W Jenkins; Robert S B Clark; Samuel A Tisherman; Patrick M Kochanek
Journal:  J Neurotrauma       Date:  2012-08-10       Impact factor: 5.269

4.  Development of an Animal Model for Burn-Blast Combined Injury and Cardiopulmonary System Changes in the Early Shock Stage.

Authors:  Quan Hu; Jiake Chai; Sen Hu; Jun Fan; Hong-Wei Wang; Li Ma; Hong-Jie Duan; Lingying Liu; Hongming Yang; Bai-Ling Li; Yi-He Wang
Journal:  Indian J Surg       Date:  2014-05-14       Impact factor: 0.656

5.  Polynitroxylated pegylated hemoglobin: a novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice.

Authors:  David K Shellington; Lina Du; Xianren Wu; Jennifer Exo; Vincent Vagni; Li Ma; Keri Janesko-Feldman; Robert S B Clark; Hülya Bayir; C Edward Dixon; Larry W Jenkins; Carleton J C Hsia; Patrick M Kochanek
Journal:  Crit Care Med       Date:  2011-03       Impact factor: 7.598

6.  Hemorrhagic shock shifts the serum cytokine profile from pro- to anti-inflammatory after experimental traumatic brain injury in mice.

Authors:  Steven L Shein; David K Shellington; Jennifer L Exo; Travis C Jackson; Stephen R Wisniewski; Edwin K Jackson; Vincent A Vagni; Hülya Bayır; Robert S B Clark; C Edward Dixon; Keri L Janesko-Feldman; Patrick M Kochanek
Journal:  J Neurotrauma       Date:  2014-08-15       Impact factor: 5.269

7.  Managing traumatic brain injury secondary to explosions.

Authors:  Paula Burgess; Ernest E Sullivent; Scott M Sasser; Marlena M Wald; Eric Ossmann; Vikas Kapil
Journal:  J Emerg Trauma Shock       Date:  2010-04

8.  MRI assessment of cerebral blood flow after experimental traumatic brain injury combined with hemorrhagic shock in mice.

Authors:  Lesley M Foley; Alia M Iqbal O'Meara; Stephen R Wisniewski; T Kevin Hitchens; John A Melick; Chien Ho; Larry W Jenkins; Patrick M Kochanek
Journal:  J Cereb Blood Flow Metab       Date:  2012-10-17       Impact factor: 6.200

9.  Hemorrhagic shock after experimental traumatic brain injury in mice: effect on neuronal death.

Authors:  Alia Marie Dennis; M Lee Haselkorn; Vincent A Vagni; Robert H Garman; Keri Janesko-Feldman; Hülya Bayir; Robert S B Clark; Larry W Jenkins; C Edward Dixon; Patrick M Kochanek
Journal:  J Neurotrauma       Date:  2009-06       Impact factor: 5.269

10.  Blast-related brain injury: imaging for clinical and research applications: report of the 2008 st. Louis workshop.

Authors:  Tammie L S Benzinger; David Brody; Sylvain Cardin; Kenneth C Curley; Mark A Mintun; Seong K Mun; Kenneth H Wong; Jean R Wrathall
Journal:  J Neurotrauma       Date:  2009-12       Impact factor: 5.269

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