Literature DB >> 16499947

Accelerated decarboxylation of 1,3-dimethylorotic acid in ionic liquid.

Freeman M Wong1, Weiming Wu.   

Abstract

The solvent effect of ionic liquids on the decarboxylation of 1,3-dimethylorotic acid and its analogue in ionic was investigated. The rate acceleration observed was proposed to be a result of the stabilization of the zwitterionic intermediates by the charged groups available in these special solvents.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16499947     DOI： 10.1016/j.bioorg.2006.01.001

Source DB:  PubMed          Journal:  Bioorg Chem        ISSN： 0045-2068            Impact factor:   5.275


  6 in total

1.  Convenient synthesis of N1-substituted orotic acid derivatives.

Authors:  Jeannette T Bowler; Caitlin R Clausen; Daniel J Blackburn; Weiming Wu
Journal:  Tetrahedron Lett       Date:  2014-11-19       Impact factor: 2.415

2.  Stability of the 6-carbanion of uracil analogues: mechanistic implications for model reactions of orotidine-5'-monophosphate decarboxylase.

Authors:  Freeman M Wong; Christina C Capule; Weiming Wu
Journal:  Org Lett       Date:  2006-12-21       Impact factor: 6.005

3.  Carbanions from decarboxylation of orotate analogs: stability and mechanistic implications.

Authors:  Fong Ying Yeoh; Roxanne R Cuasito; Christina C Capule; Freeman M Wong; Weiming Wu
Journal:  Bioorg Chem       Date:  2007-04-02       Impact factor: 5.275

4.  Stabilities of Uracil and Pyridone-Based Carbanions: A Systematic Study in the Gas Phase and Solution and Implications for the Mechanism of Orotidine-5'-Monophosphate Decarboxylase.

Authors:  Nicholas A Senger; Carly E Bliss; James R Keeffe; Scott Gronert; Weiming Wu
Journal:  Tetrahedron       Date:  2013-07-01       Impact factor: 2.457

5.  Orotic acid decarboxylation in water and nonpolar solvents: a potential role for desolvation in the action of OMP decarboxylase.

Authors:  Charles A Lewis; Richard Wolfenden
Journal:  Biochemistry       Date:  2009-09-15       Impact factor: 3.162

6.  Improved synthesis of N1-substituted orotic acid derivatives.

Authors:  Nicholas A Senger; Jeannette T Bowler; Rene S Mercado; Sidney Lin; Weiming Wu
Journal:  Tetrahedron Lett       Date:  2013-08-07       Impact factor: 2.415
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.