| Literature DB >> 1649986 |
T Nakagawa1, S Kakehata, N Akaike, S Komune, T Takasaka, T Uemura.
Abstract
The physiological and pharmacological properties of the Ca2+ channel in outer hair cells (OHCs) freshly isolated from guinea pig cochlea were investigated using a whole-cell patch-clamp technique. The Ca2+ current (ICa) was activated from a membrane potential of -20 mV and reached peak value around +20 mV in external solution containing 20 mM Ca2+ at a holding potential of -70 mV. The peak amplitude of ICa increased in a hyperbolic manner with increasing extracellular Ca2+ concentration. The ion selectively was Ba2+ much greater than Ca2+ greater than or equal to Sr2+. It was concluded that the Ca2+ channel in OHCs of guinea pig is of the L-type.Entities:
Mesh：
Substances：
Year: 1991 PMID： 1649986 DOI： 10.1016/0304-3940(91)90136-h
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046