PURPOSE: To discuss the pathophysiology and the current treatment approaches for the dysregulation of glucose metabolism in the context of human immunodeficiency virus (HIV) infection. DATA SOURCES: Selected research, clinical studies, clinical guidelines, and review articles. CONCLUSIONS: In HIV infection, multiple factors are associated with the pathogenesis of glucose dysregulation. Studies suggest that protease inhibitors, a class of antiretroviral agent, as well as viral factors, lipodystrophy, hepatitis C infection, injection drug use, and second-generation antipsychotics have been implicated in the development of glucose disorders and diabetes. Current treatment recommendations are based on extrapolated data from non-HIV diabetic patients. More research is needed to establish the most appropriate management for the disorders of glucose metabolism in the context of HIV infection. IMPLICATIONS FOR PRACTICE: If left untreated, patients are at increased risk for cardiovascular disease and complications associated with untreated diabetes.
PURPOSE: To discuss the pathophysiology and the current treatment approaches for the dysregulation of glucose metabolism in the context of human immunodeficiency virus (HIV) infection. DATA SOURCES: Selected research, clinical studies, clinical guidelines, and review articles. CONCLUSIONS: In HIV infection, multiple factors are associated with the pathogenesis of glucose dysregulation. Studies suggest that protease inhibitors, a class of antiretroviral agent, as well as viral factors, lipodystrophy, hepatitis C infection, injection drug use, and second-generation antipsychotics have been implicated in the development of glucose disorders and diabetes. Current treatment recommendations are based on extrapolated data from non-HIV diabeticpatients. More research is needed to establish the most appropriate management for the disorders of glucose metabolism in the context of HIV infection. IMPLICATIONS FOR PRACTICE: If left untreated, patients are at increased risk for cardiovascular disease and complications associated with untreated diabetes.
Authors: Mutsa Mutowo; Usha Gowda; John Chamunorwa Mangwiro; Paula Lorgelly; Alice Owen; Andre Renzaho Journal: Int J Public Health Date: 2014-11-29 Impact factor: 3.380
Authors: Anna Wilk; Katarzyna Urbanska; Shuo Yang; Jin Ying Wang; Shohreh Amini; Luis Del Valle; Francesca Peruzzi; Leonard Meggs; Krzysztof Reiss Journal: J Neurosci Res Date: 2010-12-08 Impact factor: 4.164
Authors: Elisa Gualco; Jin Ying Wang; Luis Del Valle; Katarzyna Urbanska; Francesca Peruzzi; Kamel Khalili; Shohreh Amini; Krzysztof Reiss Journal: Front Biosci (Landmark Ed) Date: 2009-01-01
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