| Literature DB >> 1649895 |
Abstract
Cytogenetic abnormalities associated with human papillomavirus (HPV) type 16 were studied using primary human and mouse epidermal keratinocytes. The E7 transforming gene of HPV-16 was found to induce chromosome duplication in epidermal keratinocytes; little or no detectable chromosome disorganization was associated with the function of the E6 gene. These results suggest that the E7 gene-linked cytogenetic effect reflects HPV-16-associated pathogenicity in the early phase of transformation.Entities:
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Year: 1991 PMID: 1649895 DOI: 10.1099/0022-1317-72-7-1569
Source DB: PubMed Journal: J Gen Virol ISSN: 0022-1317 Impact factor: 3.891