Literature DB >> 16497707

Using a cysteine-less mutant to provide insight into the structure and mechanism of CFTR.

Tip W Loo1, David M Clarke.   

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Year:  2006        PMID： 16497707      PMCID： PMC1779679          DOI： 10.1113/jphysiol.2006.108159

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


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  12 in total

1.  The chemical chaperone CFcor-325 repairs folding defects in the transmembrane domains of CFTR-processing mutants.

Authors:  Tip W Loo; M Claire Bartlett; Ying Wang; David M Clarke
Journal:  Biochem J       Date:  2006-05-01       Impact factor: 3.857

Review 2.  Cys-scanning mutagenesis: a novel approach to structure function relationships in polytopic membrane proteins.

Authors:  S Frillingos; M Sahin-Tóth; J Wu; H R Kaback
Journal:  FASEB J       Date:  1998-10       Impact factor: 5.191

3.  Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.

Authors:  J R Riordan; J M Rommens; B Kerem; N Alon; R Rozmahel; Z Grzelczak; J Zielenski; S Lok; N Plavsic; J L Chou
Journal:  Science       Date:  1989-09-08       Impact factor: 47.728

4.  Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains.

Authors:  Tip W Loo; M Claire Bartlett; David M Clarke
Journal:  J Biol Chem       Date:  2002-11-05       Impact factor: 5.157

5.  Rescue of DeltaF508 and other misprocessed CFTR mutants by a novel quinazoline compound.

Authors:  Tip W Loo; M Claire Bartlett; David M Clarke
Journal:  Mol Pharm       Date:  2005 Sep-Oct       Impact factor: 4.939

6.  Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive.

Authors:  G M Denning; M P Anderson; J F Amara; J Marshall; A E Smith; M J Welsh
Journal:  Nature       Date:  1992-08-27       Impact factor: 49.962

7.  The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gating.

Authors:  Liying Cui; Luba Aleksandrov; Yue-Xian Hou; Martina Gentzsch; Jey-Hsin Chen; John R Riordan; Andrei A Aleksandrov
Journal:  J Physiol       Date:  2006-02-16       Impact factor: 5.182

8.  Val133 and Cys137 in transmembrane segment 2 are close to Arg935 and Gly939 in transmembrane segment 11 of human P-glycoprotein.

Authors:  Tip W Loo; M Claire Bartlett; David M Clarke
Journal:  J Biol Chem       Date:  2004-01-28       Impact factor: 5.157

9.  Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites.

Authors:  Tip W Loo; M Claire Bartlett; David M Clarke
Journal:  J Biol Chem       Date:  2003-10-01       Impact factor: 5.157

10.  Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

Authors:  Nicoletta Pedemonte; Gergely L Lukacs; Kai Du; Emanuela Caci; Olga Zegarra-Moran; Luis J V Galietta; A S Verkman
Journal:  J Clin Invest       Date:  2005-08-25       Impact factor: 14.808
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  2 in total

1.  Functional differences in pore properties between wild-type and cysteine-less forms of the CFTR chloride channel.

Authors:  Ryan G Holstead; Man-Song Li; Paul Linsdell
Journal:  J Membr Biol       Date:  2011-07-28       Impact factor: 1.843

2.  Role of the juxtamembrane region of cytoplasmic loop 3 in the gating and conductance of the cystic fibrosis transmembrane conductance regulator chloride channel.

Authors:  Yassine El Hiani; Paul Linsdell
Journal:  Biochemistry       Date:  2012-05-07       Impact factor: 3.162
  2 in total

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