Marie-Laure Bocca1, Pierre Denise. 1. Université Paris Sud-11, UPRES EA 1609, UFR STAPS, F-91405 Orsay Cedex, France. marie-laure.bocca@staps.u-psud.fr
Abstract
OBJECTIVE: Previous research has shown that total sleep deprivation (TSD) of short duration (one night) affects performance to some cognitive tasks subserved by a fronto-parietal network. The aim of our study was to assess the effects of TSD on visuo-spatial attention, which is a cognitive task involving this network. Specifically, the disengagement of spatial attention was investigated with gap and overlap paradigms of saccadic eye movements. METHODS: Ten healthy young male subjects performed the two tasks the morning after a normal night and after a TSD night. The study was conducted using a balanced, crossover design. RESULTS: TSD significantly increased the gap effect (difference of latency between overlap and gap). CONCLUSIONS: This result can be interpreted as an impaired disengagement of attention after TSD. As the peak velocity, which is an indicator of alertness, was not altered by TSD, the impairment in the disengagement of spatial attention does not result from a decrease in alertness. SIGNIFICANCE: This study shows that saccadic eye movements enable studying alertness and disengagement of spatial attention simultaneously. The idea that specific brain areas are affected by TSD is confirmed by our results.
OBJECTIVE: Previous research has shown that total sleep deprivation (TSD) of short duration (one night) affects performance to some cognitive tasks subserved by a fronto-parietal network. The aim of our study was to assess the effects of TSD on visuo-spatial attention, which is a cognitive task involving this network. Specifically, the disengagement of spatial attention was investigated with gap and overlap paradigms of saccadic eye movements. METHODS: Ten healthy young male subjects performed the two tasks the morning after a normal night and after a TSD night. The study was conducted using a balanced, crossover design. RESULTS:TSD significantly increased the gap effect (difference of latency between overlap and gap). CONCLUSIONS: This result can be interpreted as an impaired disengagement of attention after TSD. As the peak velocity, which is an indicator of alertness, was not altered by TSD, the impairment in the disengagement of spatial attention does not result from a decrease in alertness. SIGNIFICANCE: This study shows that saccadic eye movements enable studying alertness and disengagement of spatial attention simultaneously. The idea that specific brain areas are affected by TSD is confirmed by our results.
Authors: Guillaume Herpin; Gerome C Gauchard; Alexandre Vouriot; Bernard Hannhart; Alain Barot; Jean-Marie Mur; Denis Zmirou-Navier; Philippe P Perrin Journal: Neurotox Res Date: 2008 May-Jun Impact factor: 3.911