Literature DB >> 16497397

Pleiotropic phenotype in Entamoeba histolytica overexpressing DNA methyltransferase (Ehmeth).

Ohad Fisher1, Rama Siman-Tov, Serge Ankri.   

Abstract

The protozoan parasite Entamoeba histolytica expresses a cytosine-5 DNA methyltransferase (Ehmeth) that belongs to the Dnmt2 proteins family. The biological function of members of the Dnmt2 family is unknown. Constitutive overexpression of Ehmeth resulted in a pleiotropic phenotype that includes accumulation of multinucleated cells, upregulation of Heat shock protein 70 (HSP70) expression and resistance to oxidative stress. This pleiotropic phenotype suggests that Ehmeth plays an important role in the control of key cellular processes in the parasite.

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Year:  2006        PMID： 16497397     DOI： 10.1016/j.molbiopara.2006.01.007

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  19 in total

Review 1.  Solving the Dnmt2 enigma.

Authors:  Matthias Schaefer; Frank Lyko
Journal:  Chromosoma       Date:  2010-02       Impact factor: 4.316

2.  The Entamoeba histolytica Dnmt2 homolog (Ehmeth) confers resistance to nitrosative stress.

Authors:  Rivi Hertz; Ayala Tovy; Michael Kirschenbaum; Meirav Geffen; Tomoyoshi Nozaki; Noam Adir; Serge Ankri
Journal:  Eukaryot Cell       Date:  2014-02-21

3.  RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.

Authors:  Matthias Schaefer; Tim Pollex; Katharina Hanna; Francesca Tuorto; Madeleine Meusburger; Mark Helm; Frank Lyko
Journal:  Genes Dev       Date:  2010-08-01       Impact factor: 11.361

4.  Widespread 5-methylcytosine in the genomes of avian Coccidia and other apicomplexan parasites detected by an ELISA-based method.

Authors:  Zhenxing Gong; Hao Yin; Xueting Ma; Baohong Liu; Zhenglan Han; Lingqiao Gou; Jianping Cai
Journal:  Parasitol Res       Date:  2017-03-30       Impact factor: 2.289

5.  A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity.

Authors:  Ayala Tovy; Rama Siman Tov; Ricarda Gaentzsch; Mark Helm; Serge Ankri
Journal:  PLoS Pathog       Date:  2010-02-19       Impact factor: 6.823

6.  Growth of the protozoan parasite Entamoeba histolytica in 5-azacytidine has limited effects on parasite gene expression.

Authors:  Ibne Karim M Ali; Gretchen M Ehrenkaufer; Jason A Hackney; Upinder Singh
Journal:  BMC Genomics       Date:  2007-01-05       Impact factor: 3.969

7.  N-acetyl ornithine deacetylase is a moonlighting protein and is involved in the adaptation of Entamoeba histolytica to nitrosative stress.

Authors:  Preeti Shahi; Meirav Trebicz-Geffen; Shruti Nagaraja; Rivka Hertz; Sharon Baumel-Alterzon; Karen Methling; Michael Lalk; Mohit Mazumder; Gourinath Samudrala; Serge Ankri
Journal:  Sci Rep       Date:  2016-11-03       Impact factor: 4.379

8.  Target recognition, RNA methylation activity and transcriptional regulation of the Dictyostelium discoideum Dnmt2-homologue (DnmA).

Authors:  Sara Müller; Indra M Windhof; Vladimir Maximov; Tomasz Jurkowski; Albert Jeltsch; Konrad U Förstner; Cynthia M Sharma; Ralph Gräf; Wolfgang Nellen
Journal:  Nucleic Acids Res       Date:  2013-07-22       Impact factor: 16.971

9.  Multinucleation and Polykaryon Formation is Promoted by the EhPC4 Transcription Factor in Entamoeba histolytica.

Authors:  Olga Hernández de la Cruz; Laurence A Marchat; Nancy Guillén; Christian Weber; Itzel López Rosas; José Díaz-Chávez; Luis Herrera; Arturo Rojo-Domínguez; Esther Orozco; César López-Camarillo
Journal:  Sci Rep       Date:  2016-01-21       Impact factor: 4.379

10.  Proteomic Identification of Oxidized Proteins in Entamoeba histolytica by Resin-Assisted Capture: Insights into the Role of Arginase in Resistance to Oxidative Stress.

Authors:  Preeti Shahi; Meirav Trebicz-Geffen; Shruti Nagaraja; Sharon Alterzon-Baumel; Rivka Hertz; Karen Methling; Michael Lalk; Serge Ankri
Journal:  PLoS Negl Trop Dis       Date:  2016-01-06
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