| Literature DB >> 16497159 |
Haibin Wang1, Corina Ehnert, Gary J Brenner, Clifford J Woolf.
Abstract
Pain hypersensitivity after tissue injury and inflammation is contributed to by a reduction in the threshold and an increase in the responsiveness of the peripheral terminals of high-threshold nociceptor neurons, the phenomenon of peripheral sensitization. Bradykinin, acting via G-protein-coupled receptors expressed by the sensory neurons, links to multiple intracellular signaling pathways that in turn interact with voltage-gated and ligand-gated ion channels, changing their properties in such a way as to enhance the response to peripheral stimuli.Entities:
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Year: 2006 PMID： 16497159 DOI： 10.1515/BC.2006.003
Source DB: PubMed Journal: Biol Chem ISSN： 1431-6730 Impact factor: 3.915