Literature DB >> 16495580

Identification of secreted cysteine proteases from the parasitic nematode Haemonchus contortus detected by biotinylated inhibitors.

Ana P Yatsuda1, Nicole Bakker, Jeroen Krijgsveld, David P Knox, Albert J R Heck, Erik de Vries.   

Abstract

Seven cathepsin B-like cysteine proteases (CBLs) were identified from the immunoprotective excretory-secretory products of Haemonchus contortus. Two-dimensional (2-D) zymography and biotinylated inhibitors were employed to localize active CBLs in 2-D protein gels. Mass spectrometry provided the identification of AC-4, HMCP1, HMCP2, and GCP7 as well as three novel CBLs encoded by clustered expressed sequence tags.

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Year:  2006        PMID： 16495580      PMCID： PMC1418636          DOI： 10.1128/IAI.74.3.1989-1993.2006

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  28 in total

Review 1.  Lysosomal cysteine proteases: more than scavengers.

Authors:  B Turk; D Turk; V Turk
Journal:  Biochim Biophys Acta       Date:  2000-03-07

2.  NEMBASE: a resource for parasitic nematode ESTs.

Authors:  John Parkinson; Claire Whitton; Ralf Schmid; Marian Thomson; Mark Blaxter
Journal:  Nucleic Acids Res       Date:  2004-01-01       Impact factor: 16.971

Review 3.  Digestive proteases of blood-feeding nematodes.

Authors:  Angela L Williamson; Paul J Brindley; David P Knox; Peter J Hotez; Alex Loukas
Journal:  Trends Parasitol       Date:  2003-09

4.  Molecular cloning and characterization of gut-derived cysteine proteinases associated with a host protective extract from Haemonchus contortus.

Authors:  P J Skuce; D L Redmond; S Liddell; E M Stewart; G F Newlands; W D Smith; D P Knox
Journal:  Parasitology       Date:  1999-10       Impact factor: 3.234

5.  Characterization of proteinases in extracts of adult Haemonchus contortus, the ovine abomasal nematode.

Authors:  D P Knox; D L Redmond; D G Jones
Journal:  Parasitology       Date:  1993-05       Impact factor: 3.234

6.  Cathepsin B-like cysteine proteases confer intestinal cysteine protease activity in Haemonchus contortus.

Authors:  S Shompole; D P Jasmer
Journal:  J Biol Chem       Date:  2000-10-13       Impact factor: 5.157

7.  Haemonchus contortus: identification of proteases with diverse characteristics in adult worm excretory-secretory products.

Authors:  F N Karanu; F R Rurangirwa; T C McGuire; D P Jasmer
Journal:  Exp Parasitol       Date:  1993-11       Impact factor: 2.011

8.  Vaccination against the nematode Haemonchus contortus with a thiol-binding fraction from the excretory/secretory products (ES).

Authors:  N Bakker; L Vervelde; K Kanobana; D P Knox; A W C A Cornelissen; E de Vries; A P Yatsuda
Journal:  Vaccine       Date:  2004-01-26       Impact factor: 3.641

9.  Protection studies with integral membrane fractions of Haemonchus contortus.

Authors:  W D Smith; S K Smith; J M Murray
Journal:  Parasite Immunol       Date:  1994-05       Impact factor: 2.280

10.  Developmentally regulated secretion of cathepsin L-like cysteine proteases by Haemonchus contortus.

Authors:  M L Rhoads; R H Fetterer
Journal:  J Parasitol       Date:  1995-08       Impact factor: 1.276
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  11 in total

1.  Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins.

Authors:  James P Hewitson; Yvonne Harcus; Janice Murray; Maaike van Agtmaal; Kara J Filbey; John R Grainger; Stephen Bridgett; Mark L Blaxter; Peter D Ashton; David A Ashford; Rachel S Curwen; R Alan Wilson; Adam A Dowle; Rick M Maizels
Journal:  J Proteomics       Date:  2011-06-29       Impact factor: 4.044

2.  Secretome Analysis of the Pine Wood Nematode Bursaphelenchus xylophilus Reveals the Tangled Roots of Parasitism and Its Potential for Molecular Mimicry.

Authors:  Ryoji Shinya; Hironobu Morisaka; Taisei Kikuchi; Yuko Takeuchi; Mitsuyoshi Ueda; Kazuyoshi Futai
Journal:  PLoS One       Date:  2013-06-21       Impact factor: 3.240

3.  Transcriptome profiles of the protoscoleces of Echinococcus granulosus reveal that excretory-secretory products are essential to metabolic adaptation.

Authors:  Wei Pan; Yujuan Shen; Xiuming Han; Ying Wang; Hua Liu; Yanyan Jiang; Yumei Zhang; Yanjuan Wang; Yuxin Xu; Jianping Cao
Journal:  PLoS Negl Trop Dis       Date:  2014-12-11

4.  Characterization of a novel aspartyl protease inhibitor from Haemonchus contortus.

Authors:  Baojie Li; Javaid Ali Gadahi; Wenxiang Gao; Zhenchao Zhang; Muhammad Ehsan; Lixin Xu; Xiaokai Song; Xiangrui Li; Ruofeng Yan
Journal:  Parasit Vectors       Date:  2017-04-19       Impact factor: 3.876

5.  Silent Witness: Dual-Species Transcriptomics Reveals Epithelial Immunological Quiescence to Helminth Larval Encounter and Fostered Larval Development.

Authors:  Friederike Ebner; Mathias Kuhring; Aleksandar Radonić; Ankur Midha; Bernhard Y Renard; Susanne Hartmann
Journal:  Front Immunol       Date:  2018-08-15       Impact factor: 7.561

Review 6.  Cysteine proteases as digestive enzymes in parasitic helminths.

Authors:  Conor R Caffrey; Louise Goupil; Karina M Rebello; John P Dalton; David Smith
Journal:  PLoS Negl Trop Dis       Date:  2018-08-23

7.  An AC-5 cathepsin B-like protease purified from Haemonchus contortus excretory secretory products shows protective antigen potential for lambs.

Authors:  Erik De Vries; Nicole Bakker; Jeroen Krijgsveld; Dave P Knox; Albert J R Heck; Ana Patricia Yatsuda
Journal:  Vet Res       Date:  2009-04-30       Impact factor: 3.683

8.  An analysis of the transcriptome of Teladorsagia circumcincta: its biological and biotechnological implications.

Authors:  Ranjeeta Menon; Robin B Gasser; Makedonka Mitreva; Shoba Ranganathan
Journal:  BMC Genomics       Date:  2012-12-13       Impact factor: 3.969

9.  Needles in the EST haystack: large-scale identification and analysis of excretory-secretory (ES) proteins in parasitic nematodes using expressed sequence tags (ESTs).

Authors:  Shivashankar H Nagaraj; Robin B Gasser; Shoba Ranganathan
Journal:  PLoS Negl Trop Dis       Date:  2008-09-24

10.  The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery.

Authors:  Roz Laing; Taisei Kikuchi; Axel Martinelli; Isheng J Tsai; Robin N Beech; Elizabeth Redman; Nancy Holroyd; David J Bartley; Helen Beasley; Collette Britton; David Curran; Eileen Devaney; Aude Gilabert; Martin Hunt; Frank Jackson; Stephanie L Johnston; Ivan Kryukov; Keyu Li; Alison A Morrison; Adam J Reid; Neil Sargison; Gary I Saunders; James D Wasmuth; Adrian Wolstenholme; Matthew Berriman; John S Gilleard; James A Cotton
Journal:  Genome Biol       Date:  2013-08-28       Impact factor: 13.583
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