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Literature DB >> 16495571

A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei.

David M Waag¹, Michael J McCluskie, Ningli Zhang, Arthur M Krieg.

Abstract

Treatment with an oligodeoxynucleotide (ODN) containing CPG motifs (CpG ODN 7909) was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei. Protection was associated with enhanced levels of gamma interferon (IFN-gamma)-inducible protein 10, interleukin-12 (IL-12), IFN-gamma, and IL-6. Preexposure therapy with CpG ODNs may protect victims of a biological attack from glanders.

Entities: Chemical Disease Gene Species

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Year: 2006 PMID： 16495571 PMCID： PMC1418646 DOI： 10.1128/IAI.74.3.1944-1948.2006

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

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