Literature DB >> 16495269

Inactivation of herpes simplex virus clinical isolates by using a combination microbicide.

Charles E Isaacs1, Lisa Rohan, Weimin Xu, Jun Hua Jia, Timothy Mietzner, Sharon Hillier.   

Abstract

A combination microbicide using the lipid-ether 1-0-octyl-sn-glycerol (OG) (3 mM) and peptide LSA5 (9 microM) synergistically inactivated six clinical isolates of herpes simplex virus type 2 (HSV-2) by 30- to 100-fold and five of six HSV-1 isolates by 10-fold more than the sum of OG and LSA5 used individually within 30 min. OG plus LSA5 inactivated all HSV clinical isolates by > or = 1,000-fold in 10 to 40 min.

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Year:  2006        PMID： 16495269      PMCID： PMC1426429          DOI： 10.1128/AAC.50.3.1063-1066.2006

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Lentivirus-derived antimicrobial peptides: increased potency by sequence engineering and dimerization.

Authors:  S B Tencza; D J Creighton; T Yuan; H J Vogel; R C Montelaro; T A Mietzner
Journal:  J Antimicrob Chemother       Date:  1999-07       Impact factor: 5.790

2.  Antimicrobial peptides of multicellular organisms.

Authors:  Michael Zasloff
Journal:  Nature       Date:  2002-01-24       Impact factor: 49.962

Review 3.  Herpes simplex viruses: is a vaccine tenable?

Authors:  Richard J Whitley; Bernard Roizman
Journal:  J Clin Invest       Date:  2002-07       Impact factor: 14.808

4.  Topical microbicides become topical.

Authors:  John P Moore
Journal:  N Engl J Med       Date:  2005-01-20       Impact factor: 91.245

5.  Novel antimicrobial peptides derived from human immunodeficiency virus type 1 and other lentivirus transmembrane proteins.

Authors:  S B Tencza; J P Douglass; D J Creighton; R C Montelaro; T A Mietzner
Journal:  Antimicrob Agents Chemother       Date:  1997-11       Impact factor: 5.191

6.  Killing of Chlamydia trachomatis by novel antimicrobial lipids adapted from compounds in human breast milk.

Authors:  M F Lampe; L M Ballweber; C E Isaacs; D L Patton; W E Stamm
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

7.  Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides.

Authors:  H Thormar; C E Isaacs; H R Brown; M R Barshatzky; T Pessolano
Journal:  Antimicrob Agents Chemother       Date:  1987-01       Impact factor: 5.191

8.  A lipid-peptide microbicide inactivates herpes simplex virus.

Authors:  Charles E Isaacs; Jun Hua Jia; Weimin Xu
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

9.  Selective toxicity of engineered lentivirus lytic peptides in a CF airway cell model.

Authors:  Shruti M Phadke; Kazi Islam; Berthony Deslouches; Sunil A Kapoor; Donna Beer Stolz; Simon C Watkins; Ronald C Montelaro; Joseph M Pilewski; Timothy A Mietzner
Journal:  Peptides       Date:  2003-08       Impact factor: 3.750

Review 10.  The development of vaginal microbicides for the prevention of HIV transmission.

Authors:  Jonathan Weber; Kamal Desai; Janet Darbyshire
Journal:  PLoS Med       Date:  2005-05-31       Impact factor: 11.069
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  2 in total

1.  Evaluation of WLBU2 peptide and 3-O-octyl-sn-glycerol lipid as active ingredients for a topical microbicide formulation targeting Chlamydia trachomatis.

Authors:  M C Skinner; A O Kiselev; C E Isaacs; T A Mietzner; R C Montelaro; M F Lampe
Journal:  Antimicrob Agents Chemother       Date:  2009-12-14       Impact factor: 5.191

2.  Chlamydia trachomatis laboratory strains versus recent clinical isolates: implications for routine microbicide testing.

Authors:  M C Skinner; W E Stamm; M L Lampe
Journal:  Antimicrob Agents Chemother       Date:  2009-02-02       Impact factor: 5.191
  2 in total

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