Literature DB >> 1649454

MutM, a protein that prevents G.C----T.A transversions, is formamidopyrimidine-DNA glycosylase.

M L Michaels1, L Pham, C Cruz, J H Miller.   

Abstract

We have cloned chromosomal DNA bordering an insert that inactivates mutM. Sequencing of this clone has revealed that the insertion element is located between the promoter and structural gene for formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase). An overproducing clone of Fapy-DNA glycosylase complements the original mutM strain that had been isolated after EMS mutagenesis. Thus, we conclude that MutM is actually Fapy-DNA glycosylase. mutM has previously been characterized as a mutator strain that leads specifically to G.C----T.A transversions. This in vivo characterization correlates well with the mutagenic potential of one of the lesions Fapy-DNA glycosylase removes, 8-oxo-7,8-dihydro-2'-deoxyguanine (8-OxodG).

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Year:  1991        PMID： 1649454      PMCID： PMC328390          DOI： 10.1093/nar/19.13.3629

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  24 in total

1.  A Factor (or Mutator Gene) Influencing Mutation Rates in Escherichia Coli.

Authors:  H P Treffers; V Spinelli; N O Belser
Journal:  Proc Natl Acad Sci U S A       Date:  1954-11       Impact factor: 11.205

2.  Cloning of genes interrupted by Tn10 derivatives using antibiotic-resistance-carrying M13mp bacteriophages.

Authors:  M L Michaels
Journal:  Gene       Date:  1990-09-01       Impact factor: 3.688

Review 3.  Mutagenesis by apurinic/apyrimidinic sites.

Authors:  L A Loeb; B D Preston
Journal:  Annu Rev Genet       Date:  1986       Impact factor: 16.830

4.  Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome.

Authors:  M L Wood; M Dizdaroglu; E Gajewski; J M Essigmann
Journal:  Biochemistry       Date:  1990-07-31       Impact factor: 3.162

5.  mutA and mutC: two mutator loci in Escherichia coli that stimulate transversions.

Authors:  M L Michaels; C Cruz; J H Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

6.  Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichia coli.

Authors:  C J Chetsanga; T Lindahl
Journal:  Nucleic Acids Res       Date:  1979-08-10       Impact factor: 16.971

7.  Ring-opened 7-methylguanine residues in DNA are a block to in vitro DNA synthesis.

Authors:  T R O'Connor; S Boiteux; J Laval
Journal:  Nucleic Acids Res       Date:  1988-07-11       Impact factor: 16.971

8.  The mutY gene: a mutator locus in Escherichia coli that generates G.C----T.A transversions.

Authors:  Y Nghiem; M Cabrera; C G Cupples; J H Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

9.  Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.

Authors:  S Shibutani; M Takeshita; A P Grollman
Journal:  Nature       Date:  1991-01-31       Impact factor: 49.962

10.  NMR structural studies of the ionizing radiation adduct 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-Oxo-7H-dG(syn).dA(anti) alignment at lesion site.

Authors:  M Kouchakdjian; V Bodepudi; S Shibutani; M Eisenberg; F Johnson; A P Grollman; D J Patel
Journal:  Biochemistry       Date:  1991-02-05       Impact factor: 3.162
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  60 in total

1.  A novel role for Escherichia coli endonuclease VIII in prevention of spontaneous G-->T transversions.

Authors:  J O Blaisdell; Z Hatahet; S S Wallace
Journal:  J Bacteriol       Date:  1999-10       Impact factor: 3.490

2.  A phylogenomic study of DNA repair genes, proteins, and processes.

Authors:  J A Eisen; P C Hanawalt
Journal:  Mutat Res       Date:  1999-12-07       Impact factor: 2.433

3.  The Escherichia coli methyl-directed mismatch repair system repairs base pairs containing oxidative lesions.

Authors:  Jennifer Wyrzykowski; Michael R Volkert
Journal:  J Bacteriol       Date:  2003-03       Impact factor: 3.490

Review 4.  The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine).

Authors:  M L Michaels; J H Miller
Journal:  J Bacteriol       Date:  1992-10       Impact factor: 3.490

5.  Comprehensive mutation identification in an evolved bacterial cooperator and its cheating ancestor.

Authors:  Gregory J Velicer; Günter Raddatz; Heike Keller; Silvia Deiss; Christa Lanz; Iris Dinkelacker; Stephan C Schuster
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-17       Impact factor: 11.205

6.  Escherichia coli Nth and human hNTH1 DNA glycosylases are involved in removal of 8-oxoguanine from 8-oxoguanine/guanine mispairs in DNA.

Authors:  Y Matsumoto; Q M Zhang; M Takao; A Yasui; S Yonei
Journal:  Nucleic Acids Res       Date:  2001-05-01       Impact factor: 16.971

7.  Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase.

Authors:  T A Rosenquist; D O Zharkov; A P Grollman
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-08       Impact factor: 11.205

8.  Identification of the radC102 mutation. Order of the genes in the 81.5-82.0 min region of the Escherichia coli chromosome.

Authors:  I Felzenszwalb; S Boiteux; J Laval
Journal:  Nucleic Acids Res       Date:  1992-01-25       Impact factor: 16.971

9.  In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.

Authors:  W Xiao; L Samson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205

10.  A Drosophila ribosomal protein contains 8-oxoguanine and abasic site DNA repair activities.

Authors:  A Yacoub; L Augeri; M R Kelley; P W Doetsch; W A Deutsch
Journal:  EMBO J       Date:  1996-05-01       Impact factor: 11.598
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